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My friend has been ever so depressed lately. Her husband just left her and she has been having a rough time. They have four children, and my friend really needs to get her act together for the kids, especially as there is still a custody battle going on as well. She has now been given mirtazapine, thank God, but she says the mirtazapine leaves her feeling tired and unable to do much all day long. What can she do about this?

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Frankly, I would just give it a bit more time. Antidepressants such as mirtazapine can have fatigue as a side effect, and this is something that is usually a temporary hazard, that wears off after a while. Side effects like fatigue, worse depression, insomnia, and the like normally take about four to six weeks to go away.
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