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Hello,

My mom has been suffering from rheumatoid arthritis for 10 years now and her new doctor prescribed Enbrel injections. I’m trying to help her out since she’ll need to inject herself and I’ve been reading up on guidelines how to use this medication, but I’m not sure what effect on will it have if it’s been kept on the room temperature before we realized it should be almost always refrigerated? It was outside only for two hours at most and I’m hoping this won’t make it completely ineffective since it has to get adjusted to the room temperature first before it can be injected safely? Or could using not refrigerated Enbrel cause some side effects? I’ve been trying to reach the pharmacist, but no luck so far.

Thanks for your help

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Hi,

 

I think it would be the best if you contacted the pharmacy and explained what happened. But Enbrel has to be refrigerated when you store it because it's considered to be bioactive substance, like the vaccines. It contains proteins that get degraded at room temperature, but it doesn't happen in seconds, of course, because they added preservatives that should keep the active ingredient of Enbrel at least somewhat safe at room temperature. But like I said, it would be the best that you ask the pharmacist directly, simply because you might need to get the medicine replaced. I think only two hours most likely didn't do any harm, but you have to check.

Wish you all the best,

Nicole

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Enbrel storage fridge stopped working probably 12 hrs before I noticed temp was 66 inside. contacted Enbrel really didn't get a good answer was told to call my Dr. I don't think a pharmacist would give any better info. I did take Enbrel to daughters house and refrigerate it. Do you know of anyone who could answer my question. Is it safe too use ? it is way too expensive to throw out, getting it replaced before my insurance will cover it is not likely.It's hard to believe such a simple question can't be answered. Am I the only person whose fridge ever went out. I would think someone would know. Thank you
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Enbrel package insert clarifies the following, "If needed, you may store the Enbrel prefilled syringe, SureClick autoinjector, Enbrel Mini cartridge, or the dose tray for the multi-dose vial at room temperature between 68°F to 77°F (20°C to 25°C) for up to 14 days. Once Enbrel has reached room temperature, do not put it back in the refrigerator"

Thus, you are fine as long as you use it and don't put it back in the refrigerator.
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Thank you for the reply, I had a months dose 8 trays. I appreciate you taking the time to answer this.
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It's good for two weeks after being refrigerated. Do not put it back in the fridge after being out 15 minutes.
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