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Hi, I am a 36 yr old married female. I was originally dx with MDD (Major Depression Disorder) and Anxiety about 15 years ago. I have been on over 5 different antidepressants as well as Wellbutrin and Abilify and nothing has helped. I have always had memory and focusing problems since childhood. I could never read as fast as the other kids and even after finishing I wouldn't remember what I read. My hyperness was only shown through my constant talking. I was a social butterfly. (My sister and brother had the same issues growing up in school) I have been through countless jobs, never able to keep one because I would have problems in performance. I would simply forget how to complete a task that has been demonstrated and explained to me numerous times. Like I could do it for a while and then get lost all of a sudden and then that was it... I could no longer do my job. At the moment I am not working. So my doctor recently (about 1 1/2 to 2 months ago) said she feels that I have undiagnosed ADHD. So I was started on Adderall 5mg IR 2 x day for 2 wks. Then moved to 10mg 2 x day (not feeling any effects positive or negative) then moved up to 20mg 2 x day for the last 3 wks. Now I still do not feel anything positive effects... Still tired, no motivation, and scatter brained. What I do feel is appetite lose, dry mouth and  shortness of breath. My chest always feels heavy. If I try to do chores around the house, talk to much, try to eat and sometimes when I am doing nothing at all I get winded fast and am struggling to take a full beath. I feel like I can never breath in completely. Like I am a asthmatic. All of this causes me to get anxious... and rightly so I think. So the doctor I have been seeing for years leaves the practice. I see a new doctor. She sees all the antidepressants I have tried and failed. I tell her my experience on the Adderall. She tells me that first off all I have Treatment Resistance Depression(antidepressants don't work on me). As far as the Adderall is concerned... maybe it is to high. I said alright but I am still not getting any positive effects. Then she says that maybe my antidepressants are not working because I am deficient in this folat called L-Methylfolate which provents dopamine, serotonin, norepinephrine and the neurotransmitters to produce. So she gave me Deplin supplement (which insurance does not cover because it is a "medical food" so it is $80 a month) I asked her if I should stop the Adderall and she said no. Don't change any of your meds because she wants to see what the Deplin does (it has done NOTHING). So here I am... Depressed, anxious, scatter brained and not being able to breath right. And my breathing seems to get worse everyday. I don't like this new doctor... I decided to change to my sisters doctor who is helping her with her ADHD. But my appointment is not for 2 weeks. I have no experience with Adderall... Is this breathing thing normal or dangerous? Does it go away? If I don't feel the positive effects from Adderall why keep me on it? Does it mean I can't take stimulants? Is stimulants the only thing that helps people with ADHD? Does Adderall not working mean I don't have ADHD and there is something wrong with my brain... like something unfixable? I am just so worried that there is no hope for me and no medication will ever work on me. I can't keep living this way. Please help.

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Hey amber, Allen here! Methamphetamine smoker,Lyme meningitis with nerve cranial palsey (facial paralysis) critical SARS COV 2 COVID-19 with a COVID related pneumothorax lung collapse survivor here! I have a idea to what may be going on! I have had the same problem as you! Except the problem started after covid-19 which was severe, my first step off the bed was a step with awful shortness of breath, so now I get shortness of breath with stimulant use, I've studied this issue for years now continuously so here's the deal on what I think the issue may be..stimulants make you release more norepinephrine, which is basically a stress hormone that increases heart rate and blood flow to your muscles. Since beta blockers prevent norepinephrine from touching the heart muscles, you won't get that "fight or flight" response, and as a result, you won't feel physically anxious and tense.

What matters is just that you take the right dose of the beta blocker, bc if you take too much then you will get that light headed feeling and your heart will get less oxygen.

Breathing exercises and meditation/mindfulness unfortunately don't do much for physical anxiety/tension caused by stimulants/adrenaline. It only helps with rumination (but not when you're ruminating on the unpleasant physical anxiety sensations - those will only go away with a bb). Electrolytes help with headaches and muscle tension, but only to a certain extent.
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