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why are diabetics at a greater risk for having acute pyelonephritis?

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The excess glucose in the blood of diabetics binds with the proteins in the kidney to form glycated proteins which in turn react with the oxygen in the blood to form superoxide free radicals that can degrade collagen, the binding matrix of all tissues and organs. Moreover, the glycated proteins can change into hydrogen peroxide and hydroxyl radicals which can damage kidney tissues, making the kidney vulnerable to infections. Coenzyme Q10 is an antioxident that have been shown to reverse damages caused by these free radicals. I highly recommend an article posted online by Alan Gaby, M.D., on the effects of CoQ10 in restoring kidney function in end-stage kidney patients.
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