I have been on depression meds before but I am now off and feel fine without them. But I have done extensive studying on the subject. So just a few notes for you all. Every person is different, every medication is different which means that not everyone can take the same medication nor will it react the same for every person. The side effects for one person will be completely different for another. For example, my sister also has problems with depression (yes, it can run in your family, even my mother has problems) my sister took the same medication as I did and could not function properly on the medication. Where as, Effexor was the perfect med for me, and at one time I was taking a moderately high dosage every day. All I can say, is that if you find the meds you are on are not working for you, you will know and you will try another until you find the proper one. Weight gain, I think is a personal battle, depression medication can sometimes be a help or a hinderance, but only you can choose which it will be. If you on on the wrong medication, I believe weight gain will be a problem. But if you are on the right medication, you will feel wonderful and active and weight gain will not befall you. understanding depression is a journey many must take, but there are many more people than anyone realizes. Just remember that you are not alone there so many people to help you and you will find the right meds for you. Good luck to all.