I have heard in a conversation with a friend about some test that have been done on piglets. It was about testing hypothesis growth of lung parenchyma…and/or diaphragmatic paralysis reduction…I can’t clearly remember, but I was surprised with the results they mentioned about reduction of left lung weight .Can somebody explain what this was really about?
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Ok, listen in order to test hypothesis that the regional growth of lung parenchyma depends on regional distending pressure, left cervical phrenectomy was done in 2 months old piglets. The unilateral diaphragmatic paralysis reduced mean trans-pulmonary pressure in the left hemithorax. I can’t give you now exact numbers .Anyway when five piglets were killed after 48 hours, wet lung weight, total protein content and nucleic acid content did not differ from values in the five sham operated controls. They were compared. Wet weight of the left lung was reduced by 29% and of the right lung 11%, DNA by 18% .So conclusion is that these results suggest that regional growth of lung parenchyma by cell proliferation adjusted to changes in regional trans-pulmonary pressure caused by the unilateral phrenectomy.
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