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If I'm spotting suddenly after not having a period for over 3 years, is it possibly a sign of pregnancy? I'm also moody, cramping, my breasts are huge and I'm always tired. Could this just be PMS reappearing?

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Hi chrissy, there's another woman on the forums who asked a question similiar to this and yes, it is possible because Depo does have a very high efficacy rate but it can fail. Have you taken a pregnancy test yet? I think it might be a good idea just to do it for peace of mind and if it comes out positive or negative, please let us know how it turns out for you! Thanks.
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