When diagnosed with fibromyalgia, patients will often experience some type of depression to go along with their search for fibromyalgia pain relief and their decreased pain tolerance . In most cases, this is not a severe form of depression where patients are at risk for committing suicide, but instead, a medical condition referred to as a dysthymic disorder. Dysthymic disorder is mild to moderate type of depression associated
Unfortunately, even with this milder form of depression, physicians will almost always prescribe some type of anti-depressant medication . Although this is "gold-standard" of therapy for dysthymia, patients risk some dangerous side effects that could come from taking antidepressants for an extended period of time . Many fibromyalgia patients turn to supplements for their fibromyalgia instead. When considering depression specifically, St. John's wort is a common name that comes up repeatedly. Is it a good idea to use St. John's wort for fibromyalgia depression, however?
The Advantages of Using St. John's wort for Fibromyalgia Depression
St. John's wort has received a lot of scrutiny over centuries. It was first used as a medicinal herb for a number of medical ailments dating as far back as ancient Greece. In modern medicine, it is favorable as an alternative therapy for depression, anxiety, and minor wounds.
St. John's wort was put to the ultimate test to determine if it would be a good supplement for fibromyalgia. In one particular investigation, over 2,000 patients suffering from mild to moderate depression were treated with either St. John's wort, a standard antidepressant medication or a placebo to determine which was more effective at treating the depression. Investigators hoped to determine if St. John's wort was as effective as the standard antidepressant and if the side effect panel was less severe for St. John's wort compared to the standard antidepressant therapy.
When considering potential side effects, patients on standard antidepressant therapy reported side effects in 45 percent of cases compared to just 26 percent of those treated with St. John's wort.
Based on this study, it seems that St. John's wort for fibromyalgia depression should be the "gold-standard" of therapy because it works better and has fewer side effects than antidepressants. So, why isn't it? 
The Disadvantages of Using St. John's wort for Fibromyalgia Depression
One of the few red flags that pop up every time a physician is considering St. John's wort for fibromyalgia depression is the potential interactions that St. John's wort has with other medications. Doctors are wary of recommending this St. John wort on a more grand scale because this supplement for fibromyalgia reacts with many other medications and can leave patients at risk for dangerous complications . Unfortunately, when patients are already taking some medications to treat the plethora of symptoms associated with fibromyalgia, it becomes risky for patients also to consider St. John's wort.
If a woman still on her periods develops fibromyalgia, taking St. John's wort would alter the protective effects of oral contraceptive therapy and could potentially lead to pregnancy. 
When considering other side effects for St. John's wort, research studies indicate that this is a very promising medication. In a systemic review study, over 33,000 patients taking St. John's wort were analyzed compared to controls and other standard therapies for depression looking for adverse side effects. During the investigation, it was found that St. John's wort was tolerated as well as the placebos in the patient groups. Considering placebos have no active medical components and are primarily just "sugar pills," this is a promising sign. Studies also show that dropout rates in the investigation were much lower in patients taking St. John's wort compared to antidepressant medication and selective serotonin reuptake inhibitors (SSRIs; the current treatment option for major depression.)
If more research is done to determine the exact interactions between St. John's wort and other medications, it will become clearer in what situations we can not only prescribe St. John's wort as an antidepressant supplement for fibromyalgia, but also some of the other ailments that plague modern society.