Six previously healthy volunteers signed up for a drug trial to test a medicine that would be used in the treatment of rheumatoid arthritis, leukemia and multiple sclerosis. The drug was named TGN1412 and was made by pharmaceutical company TeGenero AG, based in Wurzburg, Germany and was being tested by clinical research firm Parexel.
Five men received the drug and one took placebo. Once the drugs started working, men who took them started behaving strangely, tearing their shirts complaining about the fever and their heads that felt like exploding.
While the state of four men is stabilized, one of them is still in the coma and may stay in coma for up to a year.
Scientists are working on the case, trying to find what could have triggered such reaction and at the same time treating the inflammation caused by the drug. The men affected are in a need for large amounts of fluids and their organs are unstable. Doctors say these features resemble other disorders and still can’t relate what could have provoked such reaction in the drug.

Another thing they can’t relate to is whether the men would make a full recovery or not.
Medicines and Healthcare products Regulatory Agency’s (MHRA) inspectors are on the field carrying out an investigation and it is still not known if the trail failed due to a fault in production, contamination, or an inherent problem with the drug itself.
The drug was previously tested on rabbits and monkeys and no adverse effects were reported. The researchers got the green light from the MHRA and the local ethics committee and people were given about 500 times lower dosage than the one used during the animal stage of testing. Still, things did not work as planned.