Researchers are using some new genetic techniques to determine relation between human immune system and bacteria that causes tuberculosis. They found that bacteria called Mycobacterium tuberculosis doesn’t react when macrophages which represent immune system cells initially make contact. It seems that bacterium’s genes are activated after the pathogen is enveloped by a macrophage. After that happens they remain in vacuoles which represent membranes. Scientists found that increased acidity in vacuoles that hold the bacteria becomes a trigger for Mycobacterium tuberculosis genes which express proteins.

Cause of this research is to find a way to reduce virulence of this disease. Scientists are trying to determine what process is allowing bacteria’s to survive inside of macrophages and by doing that to find more effective drug that could help in fighting tuberculosis. During the research they used a gene chips to try to identify genes that are activated under specific conditions in their environment. This helped them to determine how bacterial cells react to stress. The goal of this study is to develop bacterial fitness readouts to screen molecule libraries for molecules that may stop growth of Mycobacterium tuberculosis inside of macrophages.