Can a cortisone shot in the foot take away inflammation elsewhere. I have very arthritic knees and am a candidate for partial knee replacement. I have had pain in one foot for a few months and finally went to the Podiatrist, he diagnosed it as a nerve strain and gave me a shot of cortisone, that should give me relief, for possibly a year. That pain has disappeared, but also the knee pain is 90% better for the past five days? Is there any corelation??? Thank you. Dave