Is it possible that someone has Iron accumulation due to transfusion? My wife has it, but it is “not clear” what caused it. What can you tell me about this? She has been receiving chronic transfusion.
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Yes, it is Iron accumulation is a predictable consequence of chronic RBC transfusion. Organ toxicity begins when reticuloendothelial sites of iron storage become saturated, so liver and endocrine dysfunction creates significant morbidity. But the most serious complication is cardiotoxicity which causes arrhythmias, and congestive heart failure. Patients receiving chronic transfusion usually have their iron status monitored and managed by their physician, so I am a bit surprised with this “not clear”???
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