Hi, my grandfather has bulbar ALS, he is losing ability to swallow. He has speaking problems, and can’t communicate as he used to. What is further progression of the disease, what can be expected?
Patients with bulbar amyotrophic lateral sclerosis (ALS) are often referred to the doctor for loss of speech and disability to eat. The disease is progressive and effects different systems in organism. The neuromuscular disorders in bulbar ALS cause symptoms associated with swallowing, speech, and respiration. IN most cases bulbar disease is accepted as the worst symptoms of ALS. People who are not able to swallow have problems with nourishment, what is apart from being unpleasant endangering their health. Loss of communication is bringing these patients in isolation, and additionally complicates the disease.
Since there is no "Magic Bullet", no miracle cure breakthrough to fight ALS. It also breaks my heart to know so many innocent lives are being lost, because of this "silent killer"; therefore, I also yearn to "stop ALS" - And it is important for people to know...
Avoid Neurotoxins: Glutamine and Aspartame !!!
Glutamate is the major amino acid in certain protein-rich foods, such as eggs, and is a widely used flavoring agent,best known in the form of its sodium salt, MonoSodium Glutamate (MSG), which has been in widespread use for nearly a century and is used in most foods under more than 25 different names.
A Japanese doctor isolated the main ingredient -- MSG, or monosodium glutamate -- and started what has become a million-dollar industry. Ajinomoto’s signature product, monosodium glutamate (MSG) seasoning, was first marketed in Japan in 1909, having been discovered and patented by Kikunae Ikeda. He found that the most important compound within seaweed broth for common use was actually a glutamate salt, which seemed to give out a unique taste sensation, which he dubbed umami.
Ajinomoto is the world's largest manufacturer of aspartame, sold under the trade name Aminosweet. It acquired its aspartame business in 2000 from Monsanto for $67M.
MSG is now the most widely used flavor enhancer in the world. MSG and MSG-containing substances are used in processed food, in fast foods, and in Chinese food. They're also found in nearly all canned and frozen foods.
Russell Blaylock M.D. - A board certified neurosurgeon, author and lecturer. He attended the LSU School of Medicine in New Orleans and completed his general surgical internship and neurosurgical residency at the Medical University of South Carolina in Charleston, South Carolina, states this in his book Excitotoxins. "Kombu has been used for centuries in asian cooking to add flavor to their cooking, however, but just because it has been used for a long time throughout history doesn’t make it healthy."
If this were true we could continue painting our houses with lead-based paint and eat the nutritious paint chips that flake off. Of course, we’ve learned over the years that lead-based paint is not a very good choice for the general publics health. We live and we learn. I’ve been told that cyanide has a wonderful nutty flavor, that’s natural and could be considered organic, however, just because it tastes good doesn’t mean we should eat.
Harmful effects of localized high concentrations of glutamate in certain neurological disease conditions, such as multiple sclerosis and ALS, have been mentioned in recent literature. This has raised concerns about the safety of administering glutamine (which can be converted to glutamate), consuming foods with added glutamate, or including glutamate in the parenteral nutrition for such patients. The glutamic acid containing foods are broken down to release glutamate in the digestive tract.
Glutamate is related to its essential role as a neurotransmitter.
The levels of glutamate in the central nervous system (brain and spinal cord) are highly regulated, since the neurons have sensitive receptors for the compound.
The excess glutamate at the neuron acts as a poison; at high enough levels, the nerves exposed to glutamate can be completely and permanently damaged, so that they are no longer capable of transmitting signals.
In some neurological diseases, it is found that glutamate levels in the central nervous system become unusually high at sites of pathology. This can occur, for example, if the rate of degradation of glutamate is slowed by an impairment of the enzymes that are involved.
Also, glutamate is excreted by immune cells that take part in inflammatory processes; the result is high local concentrations at the neurons in progressive neurological diseases such as MS and ALS, Parkinson's disease and Huntington's disease are examples of neurodegenerative diseases where mitochondrial dysfunction may sensitise specific populations of neurones to excitotoxicity from synaptic glutamic acid.
Laboratory research has revealed that in the progressive, debilitating disease ALS, one of the many processes involved in disease progression appears to be damage of nerve cells by accumulation of glutamate.
Thus, while glutamate is a major component of the body, and an essential part of the nervous system, high levels localized in the nerve cells can be quite toxic, and this is readily demonstrated in animal models.
Glutamic acid [glutamate] is the principal excitatory neurotransmitter in the mammalian central nervous system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand-gated ion channels.
It is activation of these receptors that leads to depolarisation and neuronal excitation. In normal synaptic functioning, activation of excitatory amino acid receptors is transitory. However, if, for any reason, receptor activation becomes excessive or prolonged, the target neurones become damaged and eventually die.
This process of neuronal death is called excitotoxicity and appears to involve sustained elevations of intracellular calcium levels.
Impairment of neuronal energy metabolism may sensitise neurones to excitotoxic cell death. The principle of excitotoxicity has been well-established experimentally, both in in vitro systems and in vivo, following administration of excitatory amino acids into the nervous system. A role for excitotoxicity in the aetiology or progression of several human neurodegenerative diseases has been proposed, which has stimulated much research recently. This has led to the hope that compounds that interfere with glutamatergic neurotransmission may be of clinical benefit in treating such diseases.
Excessive calcium can enter the cell if the exposure to glutamate is excessive, even if that exposure is brief. In some cases the calcium channel can "lock" in the open position and allow calcium to continue streaming into the cell until the neuron dies from overexcitation. The actual cell death in such cases may occur several hours after the exposure to excess glutamate, and this is true even if the glia molecules and astrocytes have succeeded in removing the extra glutamate present in the extracellular space.
These findings point to local glutamate excess as an important factor in brain diseases. Glutamate at high enough levels in the central nervous system can cause nerve damage; these high levels are mainly the result of unusual situations such as autoimmune attacks against nervous system components (as occurs with MS and ALS)
This research shows that glutamine and glutamate are found in high concentrations in the brains of ALS patients. However glutamate exitotoxicity is almost certainly a major cause of the devastating nervous degeneration that characterizes this disease. Since glutamine is converted to glutamate, supplementing glutamine at very high levels in persons who have such neurological disorders may be contraindicated.
Since 1995, the only FDA approved "antiglutamate" drug called "Riluzole", has shown to provide "some" short term therapeutic benefit in the treatment of amyotrophic lateral sclerosis, as the drug slows the progression of the disease by inhibiting glutamate by a couple of months or so. Riluzole functions by inhibiting glutamate in neurons synthesis.
There is however evidence to show that people should be concerned about the safety of glutamine especially when used chronically as part of a lifetime anti-aging regimen. Glutamate excitotoxicity is a hot topic in current research and there are valid reasons to think that those who take glutamine for GH releasing purposes (i.e., large doses on an empty stomach) should be concerned about the dangers of glutamate excitotoxity.
One should not assume that health food stores are safe havens from these excitotoxins. In fact, I have found that many products, including supplements as well as foods, contain one or more of these toxic compounds. For example, at least one product claiming to improve memory and boost brain power, contains large doses of both glutamate and glutamine.
Glutamate is an excitatory amino acid (EAA) and a neurotransmitter. When present in excess it is an excitotoxin.
One cause of brain cell death is glutamate toxicity. Brain cells use glutamate as a neurotransmitter, but unfortunately glutamate is a double-edged sword in that it can also kill aging brain cells. The long term health consequences of such concentrated "brain treatments" are currently untested and unknown and therefore uncertain and unsafe. People who do it are human guinea pigs.
The general implication is that neurons become more vulnerable to glutamate as we age, and that this combination may precipitate or aggravate neurodegenerative diseases like Huntington's disease, Parkinson's disease, ALS, and Alzheimer's disease.
Until more is known about the risks of glutamine and glutamate, the best we can say is that multiple gram doses of glutamine on an empty stomach should almost certainly not be a part of the daily regimen of aging people who have or who hope to avoid or postpone neurodegenerative diseases.
Aspartame - An Intense Source Of Excitotoxins
Aspartame is a sweetener made from two amino acids, phenylalanine and the excitotoxin aspartate. It should be avoided at all costs.
Aspartame complaints accounts for approximately 70% of ALL complaints to the FDA. It is implicated in everything from blindness to headaches to convulsions.
Sold under dozens of brand names such as NutraSweet and Equal, aspartame breaks down within 20 minutes at room temperature into several primary toxic and dangerous ingredients:
1. DKP (diketopiperazine) (When ingested, converts to a near
duplicate of a powerful brain tumor causing agent)
2. Formic Acid (ant venom)
3. Formaldehyde (embalming fluid)
4. Methanol (causes blindness...extremely dangerous substance)
Diet soft drinks, sugar free gums, sugar free Kool Aid, Crystal Light, childrens' medications, and thousands of other products claiming to be 'low calorie', 'diet', or 'sugar free'.
Until more is known about glutamine supplementation and aspartame in relation to these brain diseases, it is recommended that patients who have nerve-damaging, chronic neurological diseases, such as ALS and multiple sclerosis, and those who have had recent neurological surgeries (such as for brain tumors) avoid and limit their intake of supplemental glutamine and aspartame.
Despite the scientific evidence making these connection to ALS, and also cancer and tumor growth. Patients are not being informed of this risk, and no work is being done by medical researchers to see if patients improve on excitotoxin-free diets.
At this point, you must be asking yourself: Why are the medical profession and scientific world not pursuing this idea?
In most cases, it is because there is little money available for research...and most researches are afraid of being attacked by the glutamate industry if they do. I find it amazing that so much research can point to the connection between human diseases and excitotoxic foods additives, but scientists seem unwilling to take that final step. Fear of professional ridicule and criticism renders impotent so many good researchers.
But what can I do about it? I'm just one voice, what can I do to stop the poisoning of our children, while the food industry is insuring their financial protection from food that is poisoning us.
Blow the whistle on MSG.
I for one am doing something about it. I am spreading the word to everyone I know in an attempt to show you the truth that the giant food chains, corporate owned politicians and media won't tell you.
The best way you can help save yourself and your children from this drug-induced epidemic, is to spread the word to everyone.
Always read the food labels to know what you’re buying before you put in in your cart, or in your mouth.