I went cold turkey off of Effexor(venaflexine) 16days ago. My doctor had me switch to Prestiq until my insurance approves Cymblata. I have had withdrawls from quiting the Venaflexine although my doctor told me I would'nt. The Prestiq is an XR, I take it at night before I go to bed. It does not last 24hrs. I start having withdrawl symptoms around 7pm. I take the Antidepressant for my Chronic Fatigue. I did not like the side affects that I was having with the Venaflexine that is why I wanted to stop taking it. I have now been approved by my insurance to take the Cymbalta but am not sure if I should. Sounds like I will have too many side affects with it as well. I took Welbutrin(Buproprion) before and did not have side affects but it really did not help with my fatigue. I am not sure what to do. Does anyone have a suggestion?