The first skin patch called Daytrana, made by Britain's Shire Pharmaceuticals Group Plc and Noven Pharmaceuticals Inc., was approved to treat the hyperactive children who have troubles taking pills and would make it easier for their parents.

The patch will carry the same warnings against use in children who already have heart problems, which have come under recent scrutiny for possible psychotic behavior such as hallucinations as well as broader heart concerns. It will also carry a separate warning about possible skin sensitivity that includes redness and bumps.

Some experts have expressed concern because the drug from the patch can enter the blood stream more directly than with a pill and also have questioned whether the patch could be shared or abused by being cut up and chewed.

Daytrana is a once-daily patch for children ages 6 to 12 that is supposed to be applied early in the morning and removed 9 hours later. It should be worn on the hip, alternating left and right sides every day, and comes in fourth strengths. Besides skin irritation, side effects can include insomnia, anorexia, significant weight loss, nausea and vomiting.