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Hello there,
Lupus nephritis is an autoimmune disease and this means that there is a problem with the body's immune system. As we all know our immune system is helping our body to defend from various attackers such as bacteria and viruses. But when someone, like your sister, is suffering from autoimmune disease the body doesn’t know the difference between good and bad substances and as a result the body is attacking healthy cells.
Since you are asking what is happening if left untreated I believe it is enough to say that the goal of the treatment for lupus nephritis is to improve kidney function and to delay kidney failure. I believe that this says everything because kidney failure leads to death in most of the cases.
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