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A friend of mine who has always had metal health problems of one kind or another was just diagnosed with major depression. She was given some medication but is already complaining about the medication and its side effects and she is thinking of quitting the drug. I am sure that would be a disaster. Perhaps if I found out what the best drug is for major depression with no side effects, that would be of help to her. What are your opinions on this?

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Antidepressants are probably among the most difficult drugs to categorize into "good and bad", let alone the best. Which drug is best for a patient is so highly individual that nobody here would be able to say anything relevant in relation to your post, other than that coming off drugs is a bad idea during a major depression.
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what would be helpful is adding another drug along with the anti-depressant, if the a-d isnt enough. Like abilify, lamictal, geodon etc...
A-d take 2-4 weeks to work so tell her to hang in there...
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