I used depo vera for three years. I decided to stop the use when I could not loose weight. I got scared when I started getting out of breath when I climbed down the stairs, my knees also felt like they were constantly giving up on me. About two years after I stopped and one pregnancy later, I was told I had multinodular goiter. I am confused because I recide in US and I have used iodized salt since 1993. No known family history of goiter. Lived in a country in Africa for 19 years.