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The effects of the caffeine are longer lasting if you drink grapefruit juice along with coffee (before or after). Grapefruit juice slows down metabolism of the caffeine in the liver (as well as many other drugs and medications) by using up the enzymes (Cytochrome P450) that are involving in breaking down the caffeine.

So, Your normal medications will have a longer half-life (which can be dangerous actually)....
and the caffeine will last longer :-S

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It has been all over the news that, due to the downturn in the economy, many uninsured low-income patients in the United States resort to splitting pills in order to make their prescriptions last longer. Drinking grapefruit juice may help benefit these patients by keeping their otherwise reduced-strength medication closer to a therapeutic level.
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Hi,
I have heard this too. Grapefruit contains the bitter taste, that is actually flavanoid if I am not mistaking. This is the reason that liver is breaking down caffeine much slower. And not just caffeine, some medication as well. I know that this can have effect on blood pressure medication, HIV medication and allergy medication. The slower the metabolism deals with these pills the longer they stay in our body.
If you ask your doctor about this, he will advice you not to take your medication with grapefruit juice. The effects of pills is not the same if it lasts longer in our body, and it can only have slower effect on medical condition that patient is suffering.
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