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Grapefruit, orange, and apple juices have been found to block drugs most commonly used to treat infections, allergies, transplant rejections, cancers, and high blood pressure.

Back in 1991, grapefruit juice has been found to increase blood concentrations of the antihypertensive drug Plendil to some dangerous levels. The scientists later realized that grapefruit juice slows down a key liver enzyme that clears Plendil, as well as other 40 prescription medications, from the body.

On the other hand, grapefruit, as well as orange and apple juices, have been showed to decrease the absorption of the following important medications:

• The allergy drug Allegra
• The antibiotics ciprofloxacin, levofloxacin and itraconazole
• The beta-blocker blood pressure drugs atenolol, celiprolol, and talinolol
• The transplant-rejection drug cyclosporine (Gengraf, Neoral)
• The cancer chemotherapy etoposide (Toposar, Vepesid)

The study authors reports that the list doesn’t end and that he and his team are on the way of discovering more drugs that are affected by these particular fruit juices.

They have pinpointed the culprit of such behaviours. It is a substance in grapefruit juice called naringin that seems to be blocking OATP1A2, a transporter molecule in the gut, which carries some drugs from the small intestine into the blood. In orange juice, a naringin-like substance called hesperidin has been identified while the apple juice culprits stay unknown for the time being.

Healthy study participants have been given fexofenadine with either a glass of grapefruit juice, a glass of water mixed with naringin, or pure water to see if the effects would differ. Taking the drug with grapefruit juice or the naringin mixture halved the amount of drug that reached the bloodstream.

The researchers are very worried about medications loosing their medical benefits in the treatment of serious medical conditions when combined with fruit juices.

They advise pills to be taken only with water or advising their doctors or pharmacists before taking medications with fruit juices or whole fruits.

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Since vitamin C's most important job is to clear toxins from bacteria and viral "germs" to heavy minerals, what's so surprising that it clears away products from Big Pharma. Is there anyone who isn't aware that most drugs are toxic in some ways? javascript:emoticon(':-(')
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