At present, depression is one of the biggest enemy of mental health.The clinical treatment of depression rely mainly on synthetic drugs. As the long-term using of these drugs, it has serious side effects, so many patients are often forced to stop treatment. Therefore,those, natural medicines and traditional Chinese medicine and the development of prescriptions to find the ideal antidepressant agent, have been attracted researchers' attention more and more. In recent years, domestic and foreign scholars, in the field of traditional Chinese medicine research, has made encouraging progress.
Berberine seems to act as an herbal antidepressant.Berberine inhibits prolyl oligopeptidase (POP) in a dose-dependent manner. Berberine is also known to bind sigma receptors like many synthetic antidepressant drugs. As berberine is a natural compound that has been safely administered to humans, preliminary results suggest the initiation of clinical trials in patients with depression, bipolar affective disorder, schizophrenia, or related diseases in which cognitive capabilities are affected, with either the extract or pure berberine. New experimental results suggest that berberine may have a potential of inhibition and prevention of Alzheimer's disease (AD) mainly through both ChEs and beta-amyloids pathways, and additionally through antioxidant capacities.

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