Benefits of testosterone replacement therapy

There are a number of benefits of testosterone replacement therapy that have been demonstrated and evaluated. It has many positive effects on mood, energy levels, and libido.
Transdermal testosterone replacement therapy particularly has been linked to positive effects on fatigue, mood, and sexual function, as well as significant increases in sexual activity.
Positive effects on body composition are also evidenced, as well as the improvements in bone density. These effects are usually noted within 3 to 6 weeks.

Disadvantages and risks of testosterone replacement therapy

There are several risks of testosterone replacement therapy and every patient should be familiar with all of them, before starting the therapy. The most serious side effects that may occur are:

Increase of the red blood cells count

For patients with anemia or low blood count, this could be beneficial but it can be potentially dangerous for a healthy individual.This is because too many blood cells can block the blood vessels and lead to a heart attack or a stroke.

Prostate effects

It is proven that testosterone therapy increases the volume of the prostate gland. But there are no researches saying that testosterone therapy increases the risk of prostate cancer. That’s why, if you have an enlarged prostate, a condition called benign prostatic hyperplasia, testosterone is contraindicated because it may worsen your symptoms. If you have a history of prostate cancer, you cannot receive testosterone therapy.

Skin reactions

They are the most common side effect when a patch is being used! This can be avoided by using gels and injections!

Infertility

This is common in young men that receive the testosterone therapy, but usually reversible after the therapy stops.

Sleep apnea

This is a very serious condition in which breathing is being disrupted during sleep. Although it isn't so common, it has been reported.

Fluid retention

Patients with history of heart failure or kidney disease should be careful.

Laboratory abnormalities

There are several laboratory abnormalities that can occur with hormone replacement and the most common are:

• Changes in cholesterol concentrations.
• Decrease in sperm count producing infertility

Other possible side effects

Acne, oily skin, breast enlargement, increased body hair and flushing have also been reported.

Lipid Abnormalities

Physiologic testosterone replacement is known to reduce total cholesterol, low density lipoprotein (LDL), and high density lipoprotein (HDL) levels.  These elevations can cause significant increase in blood viscosity.