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Norethisterone is a type of medication that patients turn to when looking to have prolongation of their ovulation cycles. This could be beneficial for older women still in reproductive age to save the limited number of eggs they have remaining if they still desire to have children. In one particular study conducted in China, it was determined that norethisterone could be effective at accomplishing this desire. In this study, 45 women took this pill to determine the effect it would have on their ovulation cycle. Doses varied from as little as 0.5 milligrams per day to over 3 milligrams per day. It was determined that as doses crept higher, there was a more obvious effect on the ovulation cycle and periods were delayed. A dose of 3mg/d corresponded to a 74 percent success rate at limiting your menstrual period. [1] It also shows favorable results in treatment of some conditions dealing with abnormal levels of estrogen levels in conditions like endometriosis. In this study, patients were given norethisterone and it was determined that patients reported better satisfaction with their pelvic pain and discomfort compared to patients not receiving treatment. 

Although these medications can do a decent job at accomplishing their goal, there are some limitations to this medication in the form of dangerous side effects. One of the first parameters to worth mentioning is the effect that this medication can have on your lipid profile. It was determined that patients who took norethisterone for a period of 15 years had significantly higher levels of triglycerides and cholesterol parameters compared to control groups. Interestingly enough, it was determined that if these medications were taken for a period of less than 15 years, noticeable reductions in triglyceride level and cholesterol levels were noted. This means that if you take norethisterone for a period less than 15 years, you are improving your health and reducing your risks of cardiovascular complications like heart attacks but if you were to take these medications for a longer period of time, this will greatly increase your chance for cardiovascular complications. [2]

Another difficult side effect that women need to deal with when taking norethisterone would be psychological changes due to this medication. Women would are using hormone replacement therapy after menopause tend to use estrogen-rich compounds to their benefit. Unfortunately, this can increase your chances for some types of cancers as well as speed up osteoporosis in women. Progesterone-rich compounds like noresthisterone do a wonderful job preventing this acceleration in calcium absorption but at one big cost. Women who took this medication tending to have depressed moods and also reported a lack of sexual desire compared to patients taking just estrogen-containing compounds. This depression could be very difficult for patients to manage and taking this medication can quickly avalanche into patients needing to take a number of anti-depressants to try to manage these potential side effects. [3]

All in all, this medication can be effective but you need to be aware of the potential benefits and side effects that can be tagged to norethisterone. Cardiovascular complications like heart attacks and strokes or suffering from long-term depression are two important categories that could easily manifest if you are not careful with this medication. 

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