Tramadol works like narcotic pain reliever. ***edited by moderator*** web addresses not allowed medicine reduces pain and act like morphine in body. This medicine works in central nervous system. Tramadol binds to opioid receptors in the brain and stop immediately pain transmission in body. Tramadol also works as antidepressant drugs by inhibiting the reuptake of certain brain chemicals. It reduces the strength of pain signal from one nerve to another