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I heard taking hydroxycut with some over the counter pain killers counteracts the weight loss effects of hydroxycut. Would any one happen to know if this is a rumor, or is fact?

 

-Meas 

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I would say this is a rumor. NSDAI (Non-Steroidal-Anti-Inflammatory) drugs do not act in the same area of the brain as the drugs contained in hydroxycut. Hydroxycut acts like any other stimulant, in that it suppresses the appetite by speeding up your metabolism (and often times speeding up YOU--after all, amphetamine was first developed for the use as an appetite suppressant; never appetite-suppressants act in a similar way, but usually have less side effects- particularly side effects that may cause abuse, like euphoria, energy, etc). Stimulants act on dopamine & norepinephrine, and to a lesser degree serotonin--thus causing the desired effects of weight loss via decreased appetite. Ibuprofen (same as "Advil"), aspirin, naproxen (Aleve), or even Tylenol for that matter, don't even TOUCH these areas of the brain. Pain relief is achieved by the action of of these drugs as cyclooxygenase (or COX, for short) inhibitors.
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^Sorry, some quick corrections to my post: 


*amphetamine was NOT originally developed as an appetite suppressant (although MDMA was developed for this purpose, the drug in "ecstasy"). Originally, amphetamine was developed as vasoconstrictor & for use in asthma. Although after its widespread use, it was very shortly thereafter legally used as an appetite suppressant (as was methamphetamine) for a long period of time--up until quite recently actually.


*AND I said "NEVER appetite-suppressants act in a similar way, but usually have less side effects."  Instead of "never" i meant "newer".. as in, newer appetite suppressant drugs act in the same areas of the brain as say amphetamine, but with less side effects. 
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...To add: you may be confusing over-the-counter pain relievers with narcotic painkillers like hydrocodone (Vicodin), oxycodone (Oxycontin/Percocet), morphine, & codeine. Through an unknown mechanism, these drugs have shown to cause an increase in appetite in some instances (although in instances of opiate/opioid dependency, high tolerance, & abuse--the alternative is usually present: loss of appetite). But I repeat, typical pain relievers (or NSAIDs) do not act on mu-opioid receptors like narcotics do, nor do they act on dopamine & norepinephrine like stimulant-appetite suppressants do; so pain relievers do NOT cause similar effects or antagonist effects. Drugs like aspirin & ibuprofen act as inhibitors of COX enzymes, & this causes minor pain relief! This is their only major neurological effect.


For some reference:
Since hydroxycut is a dietary supplement, its ingredients are hard to discover! Originally its main ingredient was ephedrine, which is a substituted amphetamine AND a methamphetamine analogue (although it does NOT have similar abuse potential or ability to cause a "high" or euphoria). But, the FDA outlawed ephedrine in the U.S. a few years ago (due to its action as a vital precursor in manufacturing meth). So, ever since, hydroxycut does NOT contain ephedrine. 

Instead, hydroxycut uses a combination of substances, caffeine and green tea extract being the main substances responsible for hydrocut's effects. There are other ingredients included in the formulation that do one of three things: 1) aide in the stimulatory-appetite suppressing action (of caffeine/tea extract); 2) affect metabolism and/or metabolic rate through a different, non-stimulatory mechanism; or 3) attempt to aide overall health by including vitamins & nutrients. Such substances known to be included in hydroxycut are: garcinia cambogia (extract), glucomannan, L-carnitine, willow bark (extract), alpha lipoic acid, chromium, potassium and calcium.
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