I am 45 and have gained 20 lbs in 1 year. I am also a registered dietitian and eat very well. I have always had a high metabolism and can out eat my husband. Since I have been taking effexor I am less hungry but have gained all the weight in my abdomen and thighs. I exercise regularly. I am going to stop this drug. It is not worth the weight gain. I will keep you posted as to whether I return to my normal 130lbs size 4.