I am a strange case of diabetes. The massive radiation administered to push my cancer into remission also damaged my pancreas. I have had diabetes for about 15 years. Cancer was about 22 years ago. My insulin-to-carb ratio is 1:1...yes, one to one. BUT, over the last couple of months my usual numbers of 90-130 are now 200-395. I take 80 units of humulin R with meals no matter how many carbs the meal is. I take 50 units of Lantus morning and night. I take metformin twice a day. Last night I was at 397. Took 50 units of Lantus and 100 units of humulin R. Woke up with a number of 230. I regularly move injection sites and all bottles of any insulin are not expired. I teach diabetes management but this is completely stumping me!!!