This is a common problem. There are 2 distinct groups roughly divided as under 50's/single males and over 50's/monogamous males . Under 50's are more likely to be a std or bacterial infection transmitted during sex.  You do not state your age but this seems to be a larger problem for the over 50's. Having ruled out  the most common causes such as std's, lice, scabies, fungus, yeast infections & bacteria, not to mention diabetes, we can begin to look at other causes: But first, before you move on - do you have any foot or toe nail infections? If so, Treat these first or together as the bacteria here can mutate to other skin areas via the ever present staph on the skin, (Staphylococcal) which will spread other bacterial and even fungal infections modifying them for other skin conditions.  Most fungal and bacterial infections of the feet can be treated with Lamisil Once, which is an absorbed skin product that lasts for many months.  One more thing to consider before we move on: washing powder and softeners;  Laundry products can cause many skin irritations. Having examined all the above:-For the over 50's Itchy scrotum often comes down to a change in hormone levels with age. If the irritation has been accompanied with a general decline in energy levels, a feeling of more vulnerability and or sexual drive/erectile dysfunction then you may be suffering from age related low testosterone or androgen production.  While general testosterone levels in the blood may read 'normal' the 'free testosterone' (bio available T) is seldom tested unless you see an endocrinologist. You may want to discuss with the endocrinologist 'primary or secondary hypogonadism'.  You may also notice that your beard growth has slowed, and that skin on the shins is thinning and drying and may also be itchy. Other related incidents are stress caused by major surgery and serious heart conditions like MI's - all cause body stress and can be physiological, psychological or a mixture of both, even bouts of depression, all have effects on physical hormone changes. So how do we treat itchy scrotum (other than scratching all day and night)? Long term, trying to correct imbalances in hormone levels may be a long process to explore with a specialist and one which may or may not work but you need to explore this as a possible long term treatment because it may not only help relieve itching but it may well transform your energy levels and life expectancy if you get this right! Short term, some creams may help, antihistamine, or cortisol based creams. Wash and dry properly two or 3 times a day. Change underpants twice a day. Get rid of those ridiculous briefs - you're not 20 any more - go buy some proper pants with a gusset and a scrotum pouch that keeps your scrotum out of contact with your legs. Loose some weight, more overweight men suffer with scrotum itch than thin men! Fact!If creams only provide short lived relief for you then try a medicated powder such as Lanacane Powder. It medicates, dry's and soothes. Ideal for a good nights sleep. I know this next bit is grose, but, if you dribble urine onto your scrotum, or are lucky enough to have sex at your age, wash immediately and dry properly, powder up!  I'm afraid that just as women suffer from hot flushes during their change, the men's version is often itchy balls & just like the women, we have to live with it the best we can! I hope this helps.  Fred,  (Clinical Medical Researcher).