Couldn't find what you looking for?

TRY OUR SEARCH!


My son is diagnosed as congenital bilateral absence of vas deferens. Doctor told us his tubes that carry sperm from the testes (he told that was vas deferens) fail to develop normally. We found out he is going to be infertile, unable to conceive a child. That made us so sad and we can’t reach why that happened to him, which genes are related for that?

Loading...


When this condition occurs in the absence of typical cystic fibrosis, most men have no health problems beside this one. It is worth to know this condition is responsible for 2 to 5 percent of all infertility in men. Genes that cause congenital bilateral absence of vas deferens is CFTR gene. More then half of men with this problem have identified mutations in the CFTR gene. This is the same gene that causes cystic fibrosis. The protein made by CFTR gene forms channel which control movements of salt and water into and out of our cells. Mutation in CFTR gene alter this protein in such a way that channel is blocked. Normally that is reason for disrupting the movement of salt and water. Result is that cells produce thick mucus that blocks the developing vas deferens. Also, CFTR gene doesn’t have to be cause for every disorder of vas deferens, sometimes there are cases with unknown reason. Some of them are associated with other structural problems of the urinary tract.
Reply

Loading...