Macrophage Migration Inhibitory Factor is protein that has ability to influence cardiac response to the loss of blood flow and oxygen to the heart. Researchers found that this protein activates an imperative cellular response enzyme called AMP – activated protein kinase (AMPK) which has ability to monitors cellular energy balance. It can also protect from heart attack injury. Scientists who found this protein said that it’s discharged in response to oxygen deprivation activated AMPK.

During the research it was found that this protein is released in response to a lack of oxygen and it causes the activation of AMPK and although it contributes to inflammatory diseases it has a protective metabolic effect in the heart. Results of the study also showed that cells from people with this genetic variant also have less activation of AMPK that can induce heart injury during a heart attack.

All these findings suggest that experts will be able to identify individuals who have a chance to suffer from cardiac damage during a heart attack based on their genetic characteristics and researchers believe that this new findings can lead to new treatment options for loss of blood flow and oxygen to the heart.