I cannot say if you are over a certain age if you can cure the effects of accutane, but if you are young you have a very good shot. I took it at 15.5, as the later stages of puberty were progressing, and it ruined me. The way this drug works is by inducing retinoic acid toxicity and 5AR inhibition in the brain. This has the effect of reducing activity in the prefrontal cortex, hippocampus, hypothalamus, and other brain regions as well. This translates throughout the entire body, affecting many people in a variety of ways. The drug decreases the density in the prefrontal cortex, severing the connections with the parts of the brain the are involved with male virility and libido. First thing, since you can't get a retinoic acid receptor antagonist legally, you will need to need to get it from a research facility and create a skin ointment to apply in order to reverse the retinoic acid toxicity. This was done on mice by a researcher named Standeven, without causing any health problems to the mice, even in very high doses. In a couple weeks you should have greater endogenous production of retinoic acid. If you wish to avoid this step you may have to wait out the toxicity, might take some time, it could be a few months before retinol uptake and retinoic acid synthesis return to normal. This first step is not necessarily or proven but it may cut down considerably on recovery time.
Next, get into a normal circadian rhythm, wake up early with the sunrise, eat a big breakfast. A lot of cholesterol, bacon and eggs, glass and half OJ to spike blood sugar for digestion and a banana or potassium citrate pills for nutrient uptake. You need to restart the brain's metabolism, and since cholesterol is the fuel for the brain, forget high protein meals, they will be useless. Avocado's may be useful, fresh fruit and nuts, get your vitamin E. Take vitamin d3 5000iu every 3-4 hours, be wary of calcium levels becaue this can cause adverse effects. Take at least 5000mcg of hydroxycobalamin, tabs that dissolve under tongue. Consider the simplified methylation protocol, search phoenix rising forum methylation protocol on google (mod if you block this part you are a true PofS).
Continue to eat high cholesterol meals, high carb maybe as well, stay away from fast food and processed. Eat raw clams, oysters, fresh herring and sardines. Do not eat soon before bed. If you don't exercise start now, begin slowly, with good form power walking. Break into sprint for 30 seconds twice during the walk. Sweat. Moderate exercise is better to start with and slowly increase intensity. Stretch before to avoid injury, accutane dries out epithelial tissue within entire body, including the joints. Weight lifting may be useless early on. Cardiovascular exercise increases BDNF brain derived neutrophic factor. Also eat meals with large amounts of turmeric, it contains curcumin which increases BDNF as well. Melatonin is useful to get to sleep at times, a good nights rest is integral to this process and allows your progress to carry over into the next day.
The idea is to increase BDNF in the entire brain, starting with the prefrontal cortex. This begins to lay down the groundwork for reward circuitry, sets up new neural pathways that were phased out by the retinoic acid treatment. Accutane is an indirect 5AR inhibitor so it interferes with the production of myelin sheaths, also retinoic acid toxicity by accutane induces a retinoic acid deficiency by decreasing the number of retinoic acid receptors in the brain which are responsible for maturation and differentiation of highly specialized neurons. These factors disrupt neuronal plasticity. This ruins communication, some people have been diagnosed as having signs of degradation similar to multiple sclerosis. The brain grows throughout our lives until we get old. We can fix the problems brought on by accutane. Find a good neurologist. Explain what I've written here, and find a drug or peptide that increases BDNF in the cerebral cortex region. One such example is memantine, an NMDAR antagonist. I have not tried it but have reason to believe it will help A LOT. Forget SSRIs, they make problems worse. For temporary sexual functioning, try pramipexole or cabergoline, dopamine receptor agonists, they aren't guaranteed but may work amazing so you don't lose your girlfriend. Take these steps and you may find much success, keep the right mindset and don't quit. Good Luck.
- Fellow accutane sufferer of 7 years. Finally recovering with this protocol, started 3 weeks ago.
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Hey, I'm the guy who posted the long protocol on this page. I was wrong about how to fix this. I am not cured but I am trying new things all the time. Several things on the list to try are water fasting, memantine/namenda, and several others. The idea is that 5AR inhibitors like accutane and finasteride reduce 5AR in the brain and possibly cerebrospinal fluid. One of the major problems is reduction in prefrontal cortex metabolism, this is the beginning of reward circuitry in the CNS.
check out the propecia help forums as well, and donate if you can, because our cure is most likely to come from that organization. accutane and finasteride can cause nearly identical symptoms.
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I just finally googled today, and I was on 3 and 1/2 rounds of accutane, the first in the early 80's where I had to pay out of pocket, $400-500/mo. I became impotent in my early 40s. I've been to Boston Group, tried viagra, etc. I never really put two and two together, but started to wonder a while back. I would be more than happy to join a law suit, I'm not sure I could get the proof that I took it, it would be trying to get very old records out of Kaiser for the first time when they didn't cover, and the 2nd time when they did.
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Hey everybody! I have been in the same boat for years. I started taking it when I was. 16 and that's when it all went to hell. After I took the medicine I was so excited before that my acne was going to be gone and I'd look so sexy. But by the time I was done with the drug. I had no Libido :-(. I am now 24 and it hasn't gotten any easier or any better. I can get there with constant attention to my junk, but when nothing's going on I'm limply.
i have to lie and say Im just nervous which I really am due to the fact that I dont get visually aroused ans they think they're not sexy or good enough. This is HORRIBLE!! I'm hunting a neorologist to fix me because I used to be able to think dirty thoughts and I'd get hard. thats the biggest thing that this drug took from me is my little guys independence. I'm glad im so happy I'm not the only one. I'm gay, so I have to say I've seen a lot of penis and theres definately so,etching wrong with us after accutane. :-( I'm down for whatever we are doing I'm sewing them anyways if I have to put my guy on a table for us to get compensation for our shitty sex livesm then I come with medical records to back this all up. Email me if you need anything.
Your ur not alone guys. Mofos sold us a nightmare.
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I was exactly like your son ... at 16 or 17, I INSISTED with my parents that I get Accutane because I hated having acne so badly. I am now 46. I have absolutely no libido whatsoever ... regardless of the source of stimulation. At this point, it has been almost 2 years since my wife and I were intimate. In hind sight, I can clearly see that my lack of libido was a major contributing factor in my 1st marriage falling apart and I can tell you very honestly, it is having a severe impact on my 2nd marriage. Don't take it !
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Get off it immediately. It does permenant irreversible damage. I know. It did it to me.
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I took accutane twice and I haven't eliminated low libido yet.
Is cannabis oil or finasteryde worth to check?
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didnt realize there are so many of us, i have no treatment or cure to contribute. I guess we all in this together. Like the wrong kind of brother hood. I cant say life is good right now.
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