I had my first depo shot feb 2010 and my last one nov 2011. I have yet to have a period. March of 2012 i started having really bad cramps and was rather moody,that is not me at all.  My breast are tender at times and there is a little bleeding a few days after sex. Recently i have become extremely tired all the time and my drive to get up and go is gone.  Could all this be tied to depo? My husband and I would like kids but how can i tell i am ovulating if i do not have a period.  I had a friend who became pregnant while on the shot and another who became pregnant after without a period.