I have a couple of questions here. I am recently prescribed with Loprazolam (Dormonoct). Since Loprazolam belongs to the benzodiazepines. I have a question about benzodiazepines. Since benzo's reduce serotonin levels, wouldn’t that reduce the overall pleasure one feels if taking at recreational dosages? The half life spread can be quite large. Some are 36 - 200 hours, so is that solely based on individual metabolism, or does other factors, such as the concentration already in the body play a big part in that as well?
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Sure, some of the benzodiazepines have a large range upon the hours, depending on the person's body, if they have ate recently before taking the medication, and how fast there metabolism works. There are a large number of benzodiazepines are available, there are major differences in potency between different benzodiazepines, which is a part of why some have a shorter half life than others. For example: 0.5mg of Alprazolam is approx. equivalent to 10mg of Diazepam. Benzodiazepines also differ markedly in the speed at which they are metabolized, in the liver and eliminated in the urine. For example, the "half-life” for Triazolam is only 2-5 hours, while the half-life of diazepam is 20-100 hours, and that of an active metabolite of diazepam is 36-200 hours which means that half the active products of diazepam are still in the bloodstream up to 200 hours after a single dose. I guess your problem is insomnia since you were prescribed on Loprazolam.
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