methadose vs methadone

you are way off, just because the liquid hit you faster does not mean that it wears off sooner... In fact the liquid has a 36 hour half life and you dose once a day.. the pill form you take 6-10 hours so how can the pill last longer...IT DONT I have been on methadone for the past 7 years and have done both....

Hi Debbie...I hope you get to read this.  Thanks so much for your post. I am also from Memphis and was recently in a car accident. I did not have health insurance at the time because I had just graduated from law school. As you can imagine, I have been treated like dirt because I don't have insurance. I finally got a much needed MRI, which showed a cervical herniated disc that is impinging on the thecal sac. I don't have a primary care physician, or any other doctor that can help me, because I rarely went to the doctor before my accident. My pain is starting to completely take over my life and is causing a downward spiral of depression. Also, most days I'm unable to work, so I am in a horrible place financially. I have only been treated with pain medication after going to the emergency room, and any other doctor I've seen has made me feel like a drug addict because I was complaining of pain, even though I always had my MRI report with me. I have enjoyed reading the posts on this site because I see that I am not alone. I had no idea there was a problem with getting help for pain or that I would be trapped on my couch with no help in sight. You seem to love your doctor, so could you send me his name? Since I don't have insurance, I will have to pay out of pocket, and I certainly don't want to waste my time or money on a doctor who is scared to help those in pain.
Thanks!
Robyn

methadone is a white pill and methadose is a concentrated liquid form that can only be given in C.D.P. Chemical Dependency Programs

I've been going to the clinic for about 8 years, 4 years taking methadone and about 4our years on methadose, there both the same, just different compound structure it's all in your head

ok, should i pop it in halfs and take both halfs, or pop the whole pill? i take 40mg at once

What planet are you on?.dose & done is not Antabuse for junkies!.The only thing you get from using opiats with either one is p*****off!. Maybe you should keep your"as far as I know"answers to a subject you know something about.Just a thought.

I have been on methadose for just over three months.  I started at 30 mg and now, in this short time , am already up to 80 mg.  Each time I get dosed up 10 mg, with in a few days I start getting sick...you know... withdraws..prior to the 24 hour period.  so... they took me from 60 to 70 mg and with in four days I was getting sick by the time I got up in the morning at 7 am.  i would be sweating and shaking and nervous as hell.  so now they are having me do a special blood test to see if indeed my body is metabolizing the methadose too fast and i am probably gonna have to go to a split dose each day. it's called a "Peak's Trough" test.  you have to get your blood taken prior to getting dosed in the morning and then go get dosed and go get your blood drawn again in two or three hours. i am already sick of this c**p...it isn't even helping with the pain, which is why I got on the methadose in the first place, and now just creating more bad than good. i wasn't even told the difference until I asked.....I thought this whole time that I was on methadone.  any help , thoughts, ideas, comments...I'm not a heroin addict but been struggling with pills since my accident which started this whole problem in 2007...just for a little back round info.  thanks allI don't know how to get myself back to this comment for replies so you can email me at mollye1010 at you know aol

 

dear starrynight05...Thank you for all your, which sounds to me, like very true and valuable information. I hope you are still around and I get to chat with you a bit. I just posted a comment but because I haven't yet figured out how this sight works I will share the story again. I am on 80 mg methadose now. I started at 30 mg about a little over three months ago. I am burning through this stuff so fast and getting sick all the time. each time they up me another ten mg, within four days I am getting wd's prior to the 24 hour period and waking up sick...so then they up me again, I am good for a few days and then the pattern starts again. it is ruining me. Each day waking up sick. So I just figured out that this was the pattern a few days ago and met with the clinical director at the clinic. They want me to do a special blood test, called "Peak's Trough", to determine just how quickly I am metabolizing the methadose. I have to figure out a solution...I can't continue to live like this...it is not a life to be lived. It isn't even helping with the pain which was why I started on it in the first place. I have serious back and neck disk herniation's that push on the nerves and cause much pain....all from an accident in 2007. Since then it has been a nightmare of meds and other medical issues. Right now I just want to get off this stuff and go back to ibuprofen. No where will take me to detox unless I am down to 30 mg except for places that cost thousands of dollars which I don't have. I haven't even been able to work for a few years due to m medical conditions. I feel so trapped and don't know what to do. I read your post and thought you might be someone of sound mind to talk to. I have also been reading about "Ibogaine"...the bark of a root from Africa which is suppose to help you become free of drugs but again... one needs to be weaned down on the methadose or go back on short acting opiates prior to that therapy as well. And of course, there is still the money issue. I have a lot to offer to others and want so badly to just get better. I actually want to work in the field of addiction and prior to getting all these issues was working on my counseling certification. I want to get better and finish that so I can get my head in the field. There is so much misinformation and simply wrong doing when it comes to this field and those suffering from addiction. I have been through the ringer and just want to disapear sometimes. It is so frustrating to deal with some of these"medical , so called, Professionals" in this field. Most of them are not dedicated and are so stuck in one box of thinking. If they have read something that was true for some, like the fact that methadone is to last more than 24 hours, they just assume and believe that it is true for all people and even as doctors refuse to treat as everyone has different DNA ...no one person is a generic of another. I am so sensitive to my body and mind. When I have told some doctors what works for me for any certain illness or medical issue they sometimes get offended if it doesn't fit into the "book case" studies of solutions. I don't know if I am getting my point across... But can we talk? Can you provide any input to this problem? You sound very knowledgeable and perhaps even empathetic. Hope to hear back from you. Thanks

ive been going to a methadone clinic and since this company took over the liquid doesnt work like before ,found out they now use methadose and it sucks must be cheaper thanks methadone .

If you really want the original, get Dolophine 5mg tabs made by Lilly. Those are the real deal and the best in my opinion.

Hi I've been on Oxycontin and percocet for the past three years. My workers comp ppl wrote my pain mgmt doctor as well as myself sayin that i need to get less and wheen down. My idea was methadone cuz I took one yrs ago from a room mate that had me try it. It worked like a charm. My question is where do you get them filled? I don't live with that roommate anymore and I don't even know if my doc will say okay. can you tell me where you get it filled? Not like Walgreens or Rite aid right? Thanks and wish me good luck

Methadone hydrochloride in liquid form used for methadone maintenance patients compared to methadone tablets used to treat pain management patients is in fact completely different. To clarify the difference, a vast amount of research has been done by examining the various patents of methadone hydrochloride, contacting the United States FDA, DEA, as well as various manufacturers of methadone hydrochloride in its various forms. Methadone HLC was originally synthesized by the Germans during World War II due to the lack of availability of opioid pain medications for those that required control of moderate to severe pain when morphine and other opioid analgesics where not available.

Methadone HLC is composed of two methadone isomers: d-methadone, and l-methadone. The final products in the USA contain both d-methadone, and l-methadone isomers leaving the final methadone products with various ratios of dl-methadone. Currently there are multiple different United States patents for making methadone HLC, at least six, as listed in the references below. It is currently completely baffling to the author as to why an FDA approved medication can be made with substantial varying effects and resulting in completely different molecular structures, yet named the same.

The amount of analgesia in any particular form of methadone is due to the ratio of DL-methadone dynamic factors. There seems to be increased potency presumably because of the NMDA receptor antagonism of the d-isomer. This is why the calculated equianalgesic dose of Methadone to Morphine can range from nearly 1:1 to as much as 12:1 in the USA. In other countries that use formulations of DL-methadone with nearly none of the D-Isomer included the equianalgesic ratio can be as high as 40+:1. Hypothetically with an empirically clean L-methadone mixture, eliminating the d-isomer and its NMDA receptor antagonism effects, the analgesia of Methadone to Morphine can be nearly 50:1 ratio.

Methadone has an asymmetric carbon atom resulting in 2 enantiomeric forms,(its purity) due to the D and L isomers. It is the racemic mixture of DL-methadone that is the form commonly used clinically in MMT settings. The D-Isomer of methadone also contains N-methyl-D-aspartate, the NMDA receptor antagonist activity; as such, this is the preferred substance to be dispensed in a clinical atmosphere to prevent opiate withdrawal as well as making it difficult for a person using the racemic mixture to feel the effects of any supplemental usage of opioid substances. This mixture of methadone is 90% D-methadone to 10% L-methadone and does not vary from various manufacturers.

L-methadone, with 50 times the analgesia potency of D-methadone, is used for somatic pain management. L-methadone is responsible for respiratory depression, QT interval prolongation as well as physical and psychological dependence. The United States does not allow for a patent that is 100% pure L-methadone, but limits the ratio of DL-methadone to a ratio of 60% L-methadone and 40% D-methadone with no NMDA receptor antagonism effects. As one can surmise from this combination of DL-methadone, it is the preferred method of delivery for those patients needing analgesia for moderate to severe discomfort. This is the Methadone HLC tablets dispensed by a pharmacy for pain, however even the non racemic forms of the pills seem to abide by their ‘patent of choice’, hence the Roxanne pills seem to be manufactured different than the Mallinckrodt version of their Methadose pill. After speaking directly with both mentioned manufactures as well as others, the claim that by use of the “Abbreviated New Drug Application”(**), that it matters not what is used to make the various forms of Methadone, they all meet the FDA requirement that the end product is allowed to be dispensed as Methadone for USA consumption. The author has a huge problem with this explanation; hence my continued effort to clarify the differences to clinicians in MMT and Pain management arenas.

It is the author’s intent to present this information clarifying the misunderstanding and belief that all methadone is the same. (**): Link is included in the below references.

http://www.google.com/patents/US6897242

http://www.google.com/patents/US6008258

http://www.google.com/patents/US20100010096

http://www.google.com/patents/US3843696

http://www.google.im/patents/US5587381

http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/AbbreviatedNewDrugApplicationANDAGenerics/

http://www.ncbi.nlm.nih.gov/pubmed/9742275

http://en.wikipedia.org/wiki/Methadone

http://www.drugcite.com/label/...

http://www.iss.it/binary/farm/cont/methadone%...
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I have spent a great deal of time contacting various manufacturers of methadone, reviewing various methadone patents as well as speaking to pharmaceutical representatives in the United States FDA as well as the United States DEA to help me better understand why one substance can have different molecular structures, be manufactured with different amounts of the chemical isomers or salts of methadone thus having completely different effects on the human central nervous system. I am currently completely baffled as to why this is allowed and am making an effort to have it corrected, yet my battle goes on to help educate those who use the substances.

There are three distinctively different forms of Methadone, all of which will identify as ‘methadone’ in urine drug screens:
1) L-methadone
2) DL-methadone
3) D-methadone.

The amount of analgesia in any particular form of methadone is due to the ratio of DL-methadone dynamic factors (increased potency presumably because of the NMDA receptor antagonism) of the d-isomer. This is why the calculated equianalgesic dose of Methadone to Morphine can range from nearly 1:1 to as much as 12:1 in the United States.

L-methadone is 50 times more potent than D-methadone, and is used for pain management.
DL-Methadone is generally used for both; however it is the RATIO THAT MAKES THE DIFFERENCE. The L-methadone is responsible for QT interval prolongation, respiratory depression as well as physical and psychological dependence.

From the first patent listed: http://www.google.com/patents/US6897242
Compositions of non-racemic (Pills) mixtures of d- and l-methadone and a method of treating pain using the composition. The composition is especially useful for treating pain of mixed origin. For predominantly neuropathic pain, a mixture of predominantly d-methadone, up to about 90%, is used. For predominantly somatic pain, a mixture of predominantly l-methadone, up to about 90%, is used (**IE: Mallinckrodt Pills*). The non-racemic mixture of dl-methadone may be further combined with a pharmacologically effective amount of a nonopioid component. In another aspect of the invention, the methadone can be combined with an opioid antagonist such as naloxone, naltrexone, or the like. (**/* comment added by poster).

To view the various chemical structures of Methadone and how much they vary simply go to Google “Images” and type in “Methadone chemical structure”. Below is the link of my last view of those pages:
https://www.google.com/search?hl=en&biw=1038&bih=536&site=imghp&tbm=isch&sa=1&q=Methadone+chemical+structure&oq=Methadone+chemical+structure&gs_l=img.12...0.0.0.4046.0.0.0.0.0.0.0.0..0.0...0.0...1c..8.img.TF3oN8sJRBI

If all methadone was in fact the same, then there would be ONE, and only ONE molecular structure or ‘chemical footprint’. This is absolutely not the case with ‘Methadone’.

I am a retired pharmacologist with a PhD in pharmacology. In 2005 my nephew overdosed on a combination of methadone, Xanax, oxycodone and alcohol. I spend a great deal of my spare time now helping to educate those folks who use and/or abuse opioids and other substances to help educate them to both their beneficial effects as well as how they can become a fatal if mixed in the wrong combination.

I was on it for nine years, then all the laws changed on pain meds. My doctor could no longer prescribe it to me. He gave me 30 the last time and told me to wean myself off of it. Believe me, I know what your daughter is going through. You think you get past the withdrawals and then here it comes again. It took me almost a year to stop having withdrawals.

I found that the methadone works better than

  methadose