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actelycholene and calbindin plays what role in the body?


Calbindin-D9k is present in mammalian intestinal epithelial cells (enterocytes) and mediates the transport of calcium across the enterocytes from the apical side, where entry is regulated by the calcium channel TRPV6, to the basolateral side, where calcium pumps such as PMCA1 utilize intracellular adenosine triphosphate to pump calcium into the blood. Calbindin-D9k can also be found in the kidney and uterus in some mammalian species.

Calbindin-D28k performs a similar role in the intestine in birds and in the mammalian kidney; it is also found in a number of other neuroendocrine cells, particularly in the cerebellum. There is no homology between calbindin-D28k and calbindin-D9k, except Apart from their calcium binding domains (EF-hands): calbindin-D9k has two EF-hands, and calbindin-D28k has six.

**from Wikipedia**

The chemical compound acetylcholine (often abbreviated ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmitter used in the somatic nervous system. It is also the neurotransmitter in all autonomic ganglia.

Acetylcholine has functions both in the peripheral nervous system (PNS) and in the central nervous system (CNS) as a neuromodulator.

In the PNS, acetylcholine activates muscles, and is a major neurotransmitter in the autonomic nervous system.

In the CNS, acetylcholine and the associated neurons form a neurotransmitter system, the cholinergic system, which tends to cause excitatory actions.

**from Wikipedia**