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The use of oxytocin nasal spray has been linked to treating autism, enhancing relationships, and promoting fidelity in partners. Thus, it performs similar functions as naturally produced oxytocin.

Who would have thought that a simple nano-peptide could instigate people to give money to charity, socialize more, have more sex, stabilize intimate relationships, relieve stress, and build trust among loved ones?

"Love can make the world go round" is a popular saying for a reason, and continuous scientific investigation on ways to naturally increase oxytocin — the love and trust hormone — helps the world go round just a little bit better. 

Research describes not only the specifics of how oxytocin works in the brain, but also how it influences human behavior — trust, aggression, anxiety, bonding and social understanding. This has also led to the discovery of the synthetic administration of oxytocin, making it the first polypeptide hormone to be synthesized. [1]

Oxytocin can be administered either as a nasal spray or as an injection. Both are medically prescribed under the brand names Syntocinon and Pitocin.

Over the years, Pitocin — a laboratory-made oxytocin — has been used to curb bleeding or cause uterine contractions during spontaneous vaginal delivery. [2]

Oxytocin Nasal Spray

Oxytocin nasal spray is in dominant usage in scientific studies of psychiatric effects — the treatment of depression, autism and post-traumatic stress disorder (PTSD). This is because the administration of nasal spray evidently allows the smooth transportation of oxytocin from the bloodstream to the brain as compared to the use of the injection. [3]

However, the beauty of this intranasal administration of oxytocin comes with its good and bad sides.

Positive Effects Of Oxytocin Nasal Spray

1. Treatment of Autism

Autism represents a collection of brain developmental disorders projected by deficiencies in social interaction, and repetitive and stereotyped behaviors.

The use of oxytocin nasal spray for autism is limited. Although it may offer a potential treatment to improve behavioral difficulties in autism, its efficacy has not been properly evaluated in the young people who could benefit most.

According to a study carried out to investigate the safety, tolerability, and efficacy of oxytocin treatment in young children suffering from autism, children using oxytocin nasal spray showed significant improvements in their social responsiveness after five weeks. As such, the use of synthetic oxytocin nasal spray as an early intervention for young ones diagnosed with autism could improve their social behavioral deficits. [4]

2. Enhance Intimacy In Relationships

Relationship bliss enhances general health and happiness, but it is often difficult to keep. 

This may be caused by an underlying tension cultural tensions, Differing psychobiological natures, and divergent relationship goals. Hence, one promising solution to this underlying tension will be an intervention at the level of the psychobiology of the partners by enhancing their interpersonal connection through neurochemical means.

A particular study showed evident improvement in couples after being administered with oxytocin nasal spray. Oxytocin nasal spray increased the level of oxytocin, thereby causing an inhibition of behaviors associated with anxiety, fear, and stress, and resulted in an improvement in positive social interactions, and bond enhancing. [5]

3. It Facilitates Monogamy (Fidelity Hormone)

It is no news that marital dissatisfaction is common and healthy, and that positive relationships in marriages are often difficult to maintain. Studies show that the growing rate of divorce and marital infidelity in the world is alarming.

It is estimated that up to 72 percent of husbands and at least 54 percent of wives commit adultery, hence, more than half of marriages end in divorce. These marital consequences are a result of societal tension, stress, and emotional distress, yet remaining in a good marriage could lead to being resilient to life stressors, wellbeing, and fewer financial problems. [5]

According to a particular study, oxytocin nasal spray caused men in a monogamous relationship to be less attracted to an attractive woman on their first encounter. [6]

This study, therefore, shows that boosted oxytocin levels promote fidelity within couples in a monogamous relationship.

4. Enhance Trust Between Strangers And Facilitate Social Interaction

According to research, single doses of the intranasal spray of oxytocin could curb fear and aggressiveness, thus promoting positive social behaviors in humans. Research also shows that people who inhaled this synthetic hormone were more willing to trust strangers. [7]

Negative Effects Of Oxytocin Nasal Spray

Oxytocin nasal spray affects different people in different ways, and a study also shows it has side effects. Some could even be life threatening. Oxytocin administration and an artificial oxytocin increase has been associated with: 

  • Anaphylactoid reactions
  • Nausea and vomiting
  • Fast, irregular heartbeat
  • Hypersensitive uterine reaction
  • Aggression in defending oneself [91011]

The administration of oxytocin nasal spray should be delivered only under medical prescription and supervision, to avoid overdosage and treatment in case of adverse effects.