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Hello there,
You should definitely talk to your mother and about her concerns. If she is usually calm and happy person than something is bothering her and if two of you are very close (and it seems to me that you are) than you should try find out what is going on.
On her next regular checkup she should mention this to her doctor. I seriously doubt that she is depressed because of hepatitis but you can never know.
I hope that she will overcome whatever is bothering her and that she will manage to cope with it. As by now you need to be her supporter and take care of her as much as you can. Good luck.
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