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Hi all-I have experienced the weight gain from Coumadin as well—probably 10-15 lbs since starting it the beginning of March. It's similar to the weight I gained when I drank diet Pepsi—the same puffy feeling and the feeling that no matter what I do I can't lose the weight. After I stopped drinking the diet soda three years ago, I lost 35 pounds. My theory is that my body didn't like something in the diet Pepsi and reacted like it was poison—probably the artificial sweetener. Since warfarin is used to kill rats, it makes sense that my body would see it as poison is well. An article I read regarding diet Pepsi which I think applies to my experience with Coumadin says that when our bodies are in a constant state of stress and inflammation they mistakingly think it's a fight-or-flight situation and the body releases cortisol which makes it nearly impossible to lose weight can actually cause us to gain weight. However, I can't get off of the Coumadin because the risk is worse than the benefit. At this point, I'm going to try some different cleanses and cut out all sugar since there's not a whole lot of other things I can cut out. One thing that is always stuck with me regarding weight loss is the saying, "you lose weight and kitchen and get fit in the gym "
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