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It seems that scientists have found a candidate for a new fat-burning medication, which would help keep extra weight off, even on a high-fat diet.

This new medication is still in development but we heard that it mimics a health-boosting compound found in red wine that may prove to be a powerful weapon in the fight against diabetes and obesity.

GlaxoSmithKline drug SRT1720 was found to be around 1,000 times more potent than resveratrol in activating an enzyme that helped burn more energy and lower glucose and insulin levels in the mice study. So far, no tests have been done on humans. When tested on mice, a high daily dose of the drug for around three months, prevented the mice from gaining weight even on a diet that was high in fat. However, a lower dose of the drug was not as effective.

The drug tricked the mice metabolisms into switching to a fat-burning mode while on a high-fat diet. Fat-burning mode normally takes over when their energy levels are low.

What the researchers tried to do was activate the same enzymes that get activated when people go to the gym. When the mice were given the high dose of the drug, they gained strength and endurance, and did not develop insulin resistance, which is a condition that precedes type 2 diabetes.

Resveratrol is found in large amounts in red wine and grapes and is believed to provide numerous heath benefits, including the prevention of heart disease. A previous study from the same team showed that it lowered insulin and glucose in diabetics. The incident of cancer and heart disease among the population that consumes a great deal of red wine is dramatically less than those that don’t, even if they may also have a diet that is high in fat. Resveratrol has been demonstrated to promote the formation of new dendrites in the brain. Resveratrol and the other bioflavoniods and polyphenols are present in large amounts in bark of grape vines, twigs, and leaves. In turn, red wine, which is fermented with the skins of the grapes, twigs and seeds, etc., tends to contain a much larger amount of the beneficial substances than white wine which is fermented only from the pressed juice of the grape.

This natural compound has drawn much interest from pharmaceutical companies and scientists that paid millions of dollars in order to acquire a number of developmental medications for a range of diseases.

The first, phase I trail has proved that the treatment is safe and very well-tolerated and a wider Phase II trail is on the way that would include patients with diabetes.

Previous studies showed that the experimental medication helped lower insulin and blood sugar levels in diabetic mice within just a few weeks with no harmful side effects and there fore helped the mice live a longer life and stay healthier.

It also helped to lower cholesterol and lose a modest amount of weight compared to the mice that were given a placebo. The mice that were on the medication were also able to exercise twice as long.

SRT1720 is still a long way from being ready for the use in people, but a form of it is already being used in preventing weight gain with the benefits on the bones, heart and the rest of the body.

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This is great news for those of us who want to lose that extra bit of fat in those difficult areas. I am just wondering how much grapes one has to consume in order to obtain the therapeutic dosage of resveratrol.
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