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Hair loss is a common problem for men and women. Current treatments for severe hair loss help promote hair regrowth and prevent hair loss, but new research provides hope for growth of new hair in bald areas.

There are many products in the market currently being sold to prevent or treat baldness, but there are only two medications that are scientifically proven to reduce hair loss

These are minoxidil (brand name Rogaine) and a prescription drug called finasteride (Propecia).

Minoxidil foams or scalp lotions work by enlarging hair follicles and stimulating hair growth. Studies suggest that some hair re-growth occurs in about seven out of ten men who use minoxidil. However, results can take months to appear and side effects include scalp irritation.

While minoxidil may be bought over the counter, finasteride pills need a doctor’s prescription. Finasteride prevents hair loss in about 90 percent of users and it works by reducing the conversion of testosterone to another hormone that prevents hair from growing.

Surgical treatments for baldness include hair transplant surgery, scalp reduction, and moving scalp flaps to bald areas. These techniques involve moving small grafts or large flaps of the scalp with hair to bald areas of the head. These procedures take time and although considered generally safe, they can also have minor side effects such as bleeding and scarring.

If hair loss is associated with some disease or medication being taken, treatment of the condition may help resolve hair thinning and hair may grow back to normal without further treatment.

New Research Raises Hope for Hair Restoration

So far, traditional hair loss treatments involve removing hair follicles from a person’s own scalp and transplanting these to his bald areas. While scientists have successfully induced new hair growth in hairless rat skins, they have not been able to trigger new hair growth in the cultured skin cells of human subjects. 

About forty years ago, scientists found that hairless skin could be reprogrammed and induced to produce hair by transplanting into them cells from the deep layer of rats’ skin (dermal papillae) which grew around hair follicles.The experiment, when done on human skin, did not produce the same results.

Recently however, scientists observed that transplanted cell behavior in rats and humans differed, which could be key to the capability to induce hair growth.

By trying to manipulate human dermal cell behavior to simulate those of rats in the laboratory, the researchers were finally able to induce hairless human skin to grow new hair.

They believe that hairless epidermal skin (the superficial layer of skin) could be reprogrammed to grow new hair follicles by transplanting just a few hair cells. This could be helpful not only for alopecia but also for covering hairless skin in patients who suffer from severe burns or wounds.

The authors of the study, which was recently published in the journal Proceedings of the National Academy of the Sciences of the United States of America, state that although the results of their research is encouraging, more work is required before this type of treatment can be done in people. Nevertheless, their findings represent a significant milestone in bioengineering of hair.

  • Higgins C, Chen J, Cerise J, et al. Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth. PNAS 2013. http://www.pnas.org/content/early/2013/10/16/1309970110.full.pdf+html
  • Morin, M. Hope for the balding? Scientists trigger new hair growth. LA Times. http://www.latimes.com/science/sciencenow/la-sci-sn-hope-for-the-balding-scientists-induce-new-hair-growth-20131021,0,6856831.story#axzz2j6VqQnoB
  • McMillen, M. How to Prevent Balding. WebMD. http://www.webmd.com/skin-problems-and-treatments/hair-loss/features/how-prevent-balding
  • WebMD. Hair Loss - Topic Overview. http://www.webmd.com/skin-problems-and-treatments/hair-loss/tc/hair-loss-topic-overview
  • Mindmap by steadyhealth.com
  • Photo courtesy of Kristoferb by Wikimedia Commons : en.wikipedia.org/wiki/File:Propecia_box_and_tablet.jpg

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