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Supplemental enzymes do not have a lot of value in treating insulin resistance, the underlying cause of type 2 diabetes. They can be extremely useful, however, in treating diabetic complications such as peripheral artery disease.

Proponents of natural medicine never have found a lot of application for supplemental enzymes in treating diabetes. Some holistic doctors have had a degree of success by replacing pancreatic enzymes, such as the epinomynous pancrease, as well as the digestive enzymes amylase, protease, and lipase. These enzymes can be very helpful to diabetics whose digestive tracts have become "sluggish" after many years of the disease. They help food break down even when the digestive tract simply cannot move it efficiently due to long-term damage to the nerves empowering the gut. However, far more dramatic effects can be found in some diabetics given supplemental trypsin and chymotrypsin. Here are some examples.

1. Enzyme therapy restores circulation in diabetic feet.

Dr William Wong reports the case of a Native American man in Montana, just 45 years old, who had had poorly controlled diabetes for many years so that he developed diabetic foot disease. Poor circulation had resulted in the need to amputate several of his toes, and his doctor was considering whether to amputate the entire foot. In addition to diabetic foot problems, this individual had parasthesias, that is, numbness, tingling, and loss of sensation in his fingers, hand, and arms.

As a last resort to amputation, the man's health advisor put him on supplemental chymotrypsin and trypsin in the hopes that something would work. Within two months, normal circulation returned to his feet. They regained a healthy, pinkish tone. 

The podiatrist no longer felt that amputation would be necessary. He also regained sensation in his hands, and was able to manage his diabetes with lower doses of insulin.

2. Enzyme therapy restores kidney function.

Wong also reports the case of an 86-year-old man in Las Vegas, Nevada, who had had type 1 diabetes for over 50 years. He suffered a variety of complications. One leg had become infected and had been amputated. The other leg was grayish. swollen, and prone to infection. His entire body had a grayish cast. 

As the result of a Lasik procedure to correct nearsightedness, the man had developed scar tissue over his lens that had left him functionally blind, although he could still detect light and darkness through that eye. His kidney function was beginning to decline as he had to deal with urinary tract infections over and over again.

Also as a last-ditch therapy, this man was given supplemental chymotrypsin and trypsin. His improvement was gradual, but dramatic. 

Over the course of several months, circulation returned to his leg. Chronic ulcers on the leg healed, and it regained a healthy, rosy appearance. The scar tissue over his eye began to break up so that he was able to enjoy the benefits of his laser surgery. Amazingly, he was able not just to reduce but to eliminate his use of insulin, contrary to any expectation of his doctors.

What is so special about these two enzymes?

Chymotrypsin and trypsin are "fibrinolytic" enzymes. They slow down the rate at which the bloodstream can form tiny blood clots on a scaffolding made of the protein fibrin. This action increases circulation, which relieves a plethora of diabetes-related problems.

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