I'd like to add my 2 cents in case it helps anyone. Today is Friday, I've been on methadone for 93 days now, I missed Sunday, Tuesday and Thursday this week. I also had 5 teeth extracted Thursday and I didn't dose that day just in case it would interfere, which I was told that as long as you're not getting Stadal (SP?) That there shouldn't be an issue. I've always had a very high tolerance for opiates and general or local anaesthetic. I've seen the O.R several times and the dentist usually has to give me quite a few shots. Thursday though, my dentist maxed out at the Texas state law limit (about 20 shots) I'm not sure what he used but I gave him the Stadal heads up the day before so I know that wasn't used, plus I think Stadal is a pretty old school drug that isn't used often nowadays, but I could be wrong over all. I'm not sure if it matters but I also have Crohn's disease as well. I know today I took my 70mg of methadone around 7am, and around 7pm I snorted 50mg of oxymorphone and event after dosing today, I am currently feeling the Opana I took. Yet I didn't reach any form of numb (bottom lip/tongue/feeling that puffy fat feel that assures you you're numb) until after shot 10 or so and I got 5 to start with and was given 20 mins for it to take hold and nil. I have to return next week to get an additional 5 teeth removed and I was told flat out by my dentist that I need to stop taking whatever I am on because it is interfering. My next visit should give me a better idea of whether it's my tolerance in general for anaesthetic and pain meds or if it was really the methadone cutting into it from the day before still or just what was built up in my system. Good luck all, I hope this helps with something along the way. Thanks.