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I am a 35 year old woman who has Lupus and has had daily diahrea for at least 3 months now.  I have 3-5 bouts of it a day without fail and it is getting worse.  It wakes me every morning and I am steadily loosing weight.  I have had a colonoscopy which has revealed only hemmroids and a CT scan of my abdomen and pelvis which was fine.  I have been prescribed Nexium and Librax which have done nothing for me.  I was also given antibiotics for E. Coli and that did nothing either.  I have had stool samples and bloodwork all have which been OK, I think.  In addition to the diahrea, I also have bloating and severe loss of appetite.  

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Have you gotten an MRI to see if there are any problems further up your digestive tract that could be causing it?
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Have you have the blood test for Celiac Disease?  This is often overlooked by doctors but could answer your question.
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