Does a Carrier of the CF gene exhibit symptoms?

Guest over a year ago

Wow I'm seeing myself all over these posts. Asthma. Digestive problems IBS. Hyperemesis gravaderum with all my pregnancies all the way to delivery. I found out with my last child I'm a CF carrier. Soon as I found out I researched it and found some studies seeming to support CF carriers have a greater incidence of asthma and other CF disorders. Not to the extent of life threatening but chronic and still problematic. Reading all these post has helped me to seek more answers as 2/3 of my children were diagnosed with asthma at a young age as well they have constant stomach complaints.

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Guest over a year ago

I have just been told iam a cf carrier and I knew I would be even before I got the results as I suffer from chest related problems and also digestive problems too

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Guest over a year ago

I also am a carrier. I lost my daughter to CF in 1993. My oldest son and youngest daughter do not have CF but my daughter is D508 positive. If you Google CF Carrier and name the symptoms, you will find a ton of info. I had my gall bladder out at age 19 and this past year had bile duct stones and pancreatitis. I also have had MS since age 40 (21 yrs). My daughter who does not have CF had her 1st sinus surgery at age 4. She has PCOS, endometriosis, sinus disease and has gluten intolerance. A lot of the CF symptoms are present in carriers. You will need to find a doctor that believes there are symptoms from being a carrier or you won't get the quality care you need. I have spoken with the CF specialist in this area and he has researched the connection and firmly believes there is a definite connection. Good luck!

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Guest over a year ago

My niece who is 3 months old was recently diagnosed so my brother is a carrier, I am now concerned about being a carrier I was born early and under 3 pounds, chronic sinus and ear infections throughout my youth, diagnosed with asthma at 20 and rently had to start doing treatments at home along with my normal inhalers. What are the chances of me and our other sibling being a carrier, or even me not being diagnosed I'm worried but don't want to run to the doctor paranoid so she thinks I'm crazy, how often does it go undiagnosed I was born in 1981.

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Guest over a year ago

I completely agree. I am a carrier for CF and me, my mom, and my son all have the same cough. We constantly are trying to clear our throat. It's chronic all year round.

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Guest over a year ago

I totally agree!!! In fact tonight I went on search for answers for my 3yr old grand daughter,she is VERY tiny and under weight. She is extremely cranky! She keeps a cold and display asthma symptoms. I can't remember the last time She was dry.and free from a cold or cold like symptom.

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Guest over a year ago

If I were you, I would request your doctor test you for CF at a CF center. Two of my children have CF and the younger at age 29 would not have been diagnosed (even now as his symptoms are mild) if his sister hadn't already been diagnosed.

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Guest over a year ago

Hi does anywhere test children privately. I am carrier and would like to know if my baby is. Thank you.

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Guest over a year ago

Hi all, I came to this post because my unborn baby has been diagnosed in an ultrasonography with hyperechogenic bowel, which can be an indicator of CF. As nobody in our family has history of CF I wondered if we could be carriers, as I always had thick mucus and very salty sweat, an my wife has always bowel obstructive problems. I am i deed molecular geneticist, and the dicotomy carrier/affected is somewhat arbitrary.CFTR gene product is huge and extremely complex.Mutations identified are normally those that render it completely non functional.But if you could test the "healthy" population, you will find varying ranges of functioning as in for every gene.This are called allelles, or gene variants (like brown/black/blonde hair),.Besides, it is not that all CFTR are produced in one place and then distributed.They express locally, with different ways of regulation and context depending on the tissue, this is called pleiotropy. So if you have some variant not 100% functional, this diminished functionality may work in some cases but not always, therefore this handful of "mild" symptoms could be perfectly linked to different alleles.there are many genetic diseases that even with the same mutation show different symptoms, because of the interplay with other genes. do not give up, most doctors are afraid to admit that somethi g they didn't thought of could be right.

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Guest over a year ago

I tried to find your facebook group. My sister found out she is a carrier and I suspect I am as well and we both have symptoms. I am trying to do some research. Would love to share and learn.

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CF and much more over a year ago

I am a man of 61 years having CF, double Delta f508, from the Netherlands. My sister is 5 years younger and carrier of one Delta F508. She has had so many health problems, and still experiences, e.g: Sinusitus, chestinfections, bowelproblems, a list too long to write down. I have NO DOUBT at all, that this has to do with being a carrier.
When she coughs, I simply hear myself during a chest infection. I reallly do not understand why the so called "academics" do hardly give any attention to this phenomena of being carrier of "only" one (detectable) CF gen. Although in the Netherlands this is taken more and more serious, there is still much more work to be done. Wishing you ll the best with your search for appropriate help, regards from across the ocean.

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Guest over a year ago

One of my daughters is a CF carrier and has a lot of these symptoms. So does her dad, so we assumed she got it from him. Surprise! I just found out I am a CF carrier, but luckily I have none of these symptoms.But my husband is NOT a carrier. So this is a complicated question.

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Guest over a year ago

cc56 i have everything you mentioned as a carrier. a doctor at usc cystic fibrosis hospital told me carriers are half way between normal and cf. i have had gunky lungs my whole life and sweat like a pig, i treat salt like a food group or my blood pressure drops. i have recently developed an irregular heart rhythm which can be caused by a mineral imbalance

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Guest over a year ago

What a welcome website. I am 63 this year, my sister is 20 months younger and was diagnosed with CF when she was a baby. I was tested a few years back, as sister and I have many similar symptoms, but mine are ultimately milder, and was found to be a carrier. I have spoken to my GP about this and his response was - you've either got CF or you haven't, there's no in between. I have gut problems (IBS?), chest problems (bronchiectasis), sweat profusely, salty sweat, no energy, etc. Our mother said of us as children, your sister has CF, you were always ill.

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Guest over a year ago

Following on from my "what a welcome website" above. I forget to mention... one contributor said something like, their mucus was very thick and had form, substance. Mine is too, even when not infected, I can cough up little pieces of clear jelly (jello?) and, when infected, almost scaly like stuff. Ugghhh!!! Sorry to be so gross.

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