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I’d like to hear something about dosing drugs in hepatic absess of the liver. I heard that doses should be decreased in hepatic diseases. Is it necessary with all drugs? How can it be diagnosed?

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Production of liver enzymes is changed in liver diseases. Enzymes are responsible for drug metabolism. Decreased level of enzymes causes increasing in level of active drug in blood. That may change expected therapeutic effect. Liver function tests should be done.
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