I am a 47yr.old female who has RA and am in menopause (for5yrs now)I had a bad flare up in my ankles and was given a 40mg prednisone in my arm.I have gained weigh and have built up a high tolerance to prednisone.My question is I have noticed my breast have increased about 3 cup sizes in the last 2 months.I had a prednisone shot back in nov. and it took 2 to3 weeks to work.I would like to know if it could have been from the prednisone shot ,weight gain,or side effect from humira.I get sharp pains in themalso.I have gained weight from prednisone before and never had any thing like this.If you could advise i would appreciate it. THANK YOU FOR YOUR HELP.