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Natural or synthetic substances that have little influence on body functions by themselves, prohormones are the building blocks or precursors the body uses to make its own anabolic, muscle-building hormones.
For about 10 years, Andro was legal and available over the counter for professional athletes and amateurs alike. In 2004, however, the US Controlled Substances Act was amended to list androstenedione as a “Schedule III” controlled substance. This classification meant that it was considered less dangerous than methamphetamines, heroin, cocaine, and pain killers, but still a substance that could cause physical or psychological addiction and that now can only be prescribed for a doctor, and for no more than six months at a time. Since “growing bigger muscles” is not a medical condition, doctors cannot legally prescribe the drug in the USA for training purposes.
A highly undesirable but seldom publicized side effect of using Andro

Feminizing side effects are also a problem with other products related to androstenedione
The feminizing side effects are not just a problem with Andro. DHEA (dehydoepiandrosterone) and androstenediol, both of which are converted in the body into androstenedione, and both of which are still on the market, both can be converted into estrogen when taken in the wrong dosages. This is also a problem for 19-nor androstenedione and 19-nor androstenediol supplements. Tribulus, horny goat weed, ginseng, passionflower, and other herbal alternatives also have little or no effect on training. There simply is no stack of supplements for you to take to bring up your testosterone levels. Fortunately, taking a supplement is not the only way to build up testosterone and build up muscle, and building up muscle is not actually dependent on keeping sex hormone levels high.
Continue reading after recommendations
- Photo courtesy of Wikidudeman by Wikimedia Commons : en.wikipedia.org/wiki/File:Rawdealsteroids4.jpg
- Brown GA, Vukovich M, King DS. Testosterone prohormone supplements. Med Sci Sports Exerc. 2006 Aug, 38(8):1451-61. Review.
- Ziegenfuss TN, Berardi JM, Lowery LM. Effects of prohormone supplementation in humans: a review. Can J Appl Physiol. 2002 Dec, 27(6):628-46. Review