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Glad I found this - I thought I was going crazy. I am on Doxy actually Doryx at 150mg per day for acne. I take it every day and get the pins/needles prick sensations. It actually started with the numbness of the toes and a couple fingers. That has subsided, but the tingling and prick sensations in the skin happen every day various times of day. I've been on Doryx since June...on my second refill. I have to take it for 3 months. Might be a while before these sensations go away.

You are not alone - :)
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Same thing here! After 4 days of taking Doxy I began having crazy nerve sensation in my hands, mostly the tops, especially when washing them! I have fibromyalgia and got worried that it was that acting up again, but so glad to see its a side-affect from Doxy! Although, that in itself is troubling! lol
Hopefully, it will go away, and not be permanent.
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WOW!!! I am so glad that I found this post! I was getting a bit nervous. I was at the beach and washed my hands before eating and couldn't believe the tingeling sensation that was in my hands. It only happened when I washed my hands with cold water. Good thing I am not done with the Dox

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This post is old but just to add more info. My wife took Doxycline 1oo iv and felt severe pain on her arm, it made her scream and the nurse said that it was ok, that she could print me the side effects and that the pain that she was feeling wasn't one of them. Later the next day she had the tingling sensation on her whole body, it's October 2012 a month later and she feels like needles going through her arm and part of her face, that was her experience with this drug.

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I Have had the same reaction, I took 2 Doxy 100mg daily and after a few days i noticed tingling in my hands..almost a prickly cold feeling. Sensitive to water, hot & cold.Also a little shaky in my hands?? Even my toungue feels a little strange when  I ate some pop corn. weird!! I cut the dose back to 1 a day and the symtoms have lessend but not gone. I think it is worse if I go in the sun, I dont seem to be getting burnt more easily just the other effects.

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Boy am I glad I found these posts too! I've been on doxy for 3 days and also have the burning/cold/tingling hands and feet. It feels like I've been outside in the freezing cold and then put my hands in warm water. It's awful!! My hands are shaking too. And red up to the first knuckle. I started on doxy due to having Lyme disease and tingling fingers/toes is also a symptom of Lyme. So it's almost unbearable! I'm ok with it if its just a symptom of Lyme but if its from being on Doxy and in the sun, my doctor is a m***n!! I manage 4 tanning salons so of course I'm exposed to sun pretty much ALL day. And one of my stores is right next door to the docs office. We literally share a wall. And if that's not bad enough, I was working a work shirt when I saw her and we talked about me working next door! Ugh!!!
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This thread is about the numbness not this stupid doxy stuff. Im suffering from a serious problem and the ONE reply I find is filled with spam about a different problem.

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After my 2nd day of taking 100mg Doxy every 12 hours my feet started to have that pins and needles sensation.  Had sharp pains in my toes, ankles, and tops of feet. The pain would sometimes spread to my calves and wrists. At night, the muscles in my legs were twitchy and jumpy. The worst lasted about 4 days and although it is definitely better, my feet still hurt and are intermittently tingly, over a week after being off the medication. Someone had posted it takes 10 days for the effects to go away and someone else posted it took a year. Although I hope it doesn't take that long, I pray that it goes away for good. My poor body is so angry at me right now.

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I am sooo sooo happy I have found this. I have been on 50 mg of doxy once a day for about 6 months and was recently upped to 50 mg twice per day. Soon after upping the dose I started noticing tingling in my left hand, I really thought nothing of it but more recently it is in my hands and feet, mostly the tops as with everyone else and experienced more when I wash with cold water or cold air blows against them. They also feel like they are burning to some extent though they are not hot to the touch. I have been unbelievably worried about this, everything from pinched nerves to MS comes up when you google it but NOTHING about doxy causing this. I think I will be back in the Dr. come Monday and I will be showing him this thread...and stopping with the doxy! Feeling so much better, at least for the moment! :-D

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I am having the same reaction as well.  I am on day 7 of Doxycycline.  I began experiencing the "pins and needles" pain in my hands when I put them in water….doesn't matter if it is hot or cold.  Was in the sun today as I had not been warned to stay out of the sun.  My skin now feels as if I have poured acid on them.  No one has ever told me that this reaction could occur.  I also experienced this same feeling about 15 years ago and was told that the tingling feeling is not a side effect of the drug, but I now know that is not true.

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Omg!! Same exact thing happene to me!! Been on doxycline for 4 days was out in sun swimming today and now everytime i wash my hands i get burning and a painful tingling on top of hands and it last for about 10-15 minutes! Its crazy. The sun today felt like someone took a match to my skin so i stayed in the swimming pool for most if the day! Scary.
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I just started taking Doxy for 14 days and three days ago my hands felt like they were on fire and after going in the ocean and washing my hands they were tingling for some time. I stopped the medicine yesterday but my hands are still pink and burn at night out of nowhere. They feel so hot. Did it go away for you?? When will the burning sensation go away and when will my skin get back to normal coloring?
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I started Doxy 2 days ago for suspected RMSF (blood results not back yet).  I was prescribed 100 mg twice daily.  About 10 hours after my 2nd dose, I started feeling tingling and needle sensations in my hands and feet.  I had very little exposure to the sun and thought it might be an allergic reaction.  However, it seems like a pretty typical side affect.  Almost all of the initial RMSF symptoms have subsided after starting the Doxy with the main exception of pain behind my eyes when turning my head or looking quickly in a different direction. So it seems to be, thankfully, very effective at treating the RMSF.  It's sounding like I'll be dealing with the tingling for the balance of my Doxy prescription and about 10 days after that.  I appreciate everyone's input.

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I had the same experience however I had a history of mild carpal tunnel and so I assumed it was starting up again not linking the doxy and these symptom together right away. I even had unsuccessful cortizone shots in my wrist after almost completly loosing feeling in my finger tips. The last straw was when I and began feeling the same numbness in my thorasic area. Along with this strange sensation came moderate joint pain which was not familiar in any way to me. The pharmacist did not ever hear of any side efffect like these but after doing some research Im thinking it could be the doxy. My question is...did this numbness ever go away? I hoping this is not a permanent neurapothy. I stopped taking the doxy 3 days ago. I know its been some time since your post but any info or advice I would appreciate. Thanks
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Yes I am on doxycline as well and experiencing the same things with my hands. When I wash my hands it also feels like I was outside in freezing weather and used hot water to wash but I wasn't and I wasn't in freezing cold weather.
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