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Hi,
You have to know that dark brown urine can be from inside bleeding as well. If you have a bleeding in your bladder or maybe in your kidneys the blood will change the color of urine to dark brown. Now there is also a chance that medication cased this color change in your urine. Urethra can be irritated by many things and even this can be from medication. Drugs have a lot of side effects so I would suggest that you familiarize yourself with all side effects that the Macrodantin has. Also have you noticed any discharge from your urethra or maybe pain when you urinate? In my opinion you should wait few more days until the medication starts to kick in.
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