Adderall and Prozac Combo

luoxetine ↔ dextroamphetamine
Applies to:Prozac (fluoxetine) and Adderall (amphetamine/dextroamphetamine)
GENERALLY AVOID: Several case reports suggest that serotonin reuptake inhibitors may potentiate the pharmacologic response to sympathomimetic agents. The exact mechanism of interaction is unclear. In one case report, a patient experienced jitteriness, racing thoughts, stomach cramps, dry eyes, palpitations, tremors, and restlessness following a single dose of phentermine ingested approximately a week after she had discontinued fluoxetine. Because of the long half-life of fluoxetine and its metabolite, an interaction with fluoxetine is possible. Similar toxic reactions have been reported when fluoxetine was used concomitantly with amphetamine or phenylpropanolamine. Additionally, some sympathomimetic agents such as amphetamines may possess serotonergic activity and should generally not be administered with serotonin reuptake inhibitors because of the additive risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. The interaction was suspected in a patient treated with dexamphetamine who developed symptoms consistent with the serotonin syndrome approximately 2 weeks after the addition of venlafaxine. The medications were discontinued and the patient was given cyproheptadine for suspected serotonin syndrome, whereupon symptoms promptly resolved. A second episode occurred when dexamphetamine was subsequently resumed and citalopram added. The patient improved following cessation of citalopram on his own, and residual symptoms were successfully treated with cyproheptadine.

MANAGEMENT: In general, amphetamines and other sympathomimetic appetite suppressants should not be combined with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Close monitoring for enhanced sympathomimetic effects and possible serotonin syndrome is recommended if these agents must be used together. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

Hello, I am a 57 year old female who has been taking adderall for over 20 years for ADHD currently taking 40 mg twice a day, Prozac for depression 80mg day, gabapentin 900 mg day for anxiety, topamax 200 mg day to prevent migraines, Ativan 1 mg day for panic attacks, and geodon 20 mg day plus Zantac 300 mg as needed. I have gained 40 pounds in the last year the adderall only makes my hands shake and mouth dry. I am still just as depressed and have crying spells. I hate taking so many pills! I am married 32 years but have no desire for sex and we used to love it. I'm so fed up and don't know where to turn.

I suggest starting therapy. I think it can really help you with depression and managing your obsessive compulsive personality disorder. I would suggest finding someone who is psychodynamic. I had been on adderall for several months, have had ADHD undiagnosed my entire childhood and I'm now an adult in my mid 20s. The adderall has helped. Also, have an obsessive compulsive personality type (perfectionism as well). However, interestingly, the interaction between ADHD and that perfectionism I found comes from trying to overcompensate for the lack of concentration/planning/organization/inhibition that is associated with ADHD. Therapy can really help. With ADHD individuals often struggle with anxiety and depression too as a result. While medications can be a hit or miss. Therapy can really help you cope and tweak out what needs to be targeted in treatment. There's so much overlap in these diagnosis as far as symptoms and what came first that perpetuated the other. I found therapy really helpful..

Any physiatrist should know good and well that antidepressants are addictive. That's why you slowly increase the dosage when you begin antidepressants and you slowly decrease the dosage when you stop taking them. You have to take them regularly so your brain, and the rest of your body, can learn to fuction a new way, and there are many people who try to quit antidepressants and fail, because they are indeed addictive. They change the way that certain neurotransmitters in your brain communicate, which has the potential to alter mental behavior/ functions, physical behavior/ functions , bodily functions, etc. which can easily cause you to be dependent on the antidepressant to fuction properly

Me too dude

serotonin storm is different from serotonin syndrome, the former is what occurs with many psychedelics like mushrooms and its not malevolent, it causes no physical damage. serotonin syndrome is what could occur with this combo, and really only if the medication is abused.

they are not addictive. "Antidepressants aren't addictive in the same way substances like alcohol and heroin are. Those abusing antidepressants do not experience the cravings that other drugs cause. ... Most consider these drugs non-addictive. Others point to the withdrawal symptoms of antidepressants as evidence that a dependence can form."

The only time there MIGHT be symptoms that SEEM LIKE withdrawal is if the person on antidepressants suddenly quits cold turkey.
"This condition is known as “antidepressant discontinuation syndrome.” The Mayo Clinic notes that withdrawal symptoms are most common in people who have been taking antidepressants for six weeks or more. However, antidepressant discontinuation syndrome cannot be equated with addiction for several important reasons:
Withdrawal from antidepressants does not cause cravings for the medication.
Antidepressant users do not compulsively seek the drug.
Antidepressant users usually don’t get caught in the cycle of repeated relapse.
Using antidepressants typically does not cause negative effects on one’s personal life or health, such as job loss, accidental injuries, or financial difficulties."

so no, anti depressants are not addictive in that sense.

i really hope that anyone looking for answers does not listen to Latrena. I am very concerned that this person is using their status as "someone who works in a pharmacy" to give incorrect information regarding drugs.

You tell her!!!
F---- Idiote
She could be sued

If it makes you feel better you can always say fluoxetine and those not in the know will go fluox-eh-who

Not sure if any of you are still around. But just wanted to say this thread saved my life. None of my doctors warned me of any interactions between my Prozac and Adderall. Stopped taking Adderall when first started the Prozac to make sure I could pick up on any side effects from the new meds. Then once I took my Adderall again, something just wasnt right. By day three of diarrhea, sweats, chills, face flushed, ears flaming red, palpatations, agitation, headaches I finally searched for interactions between the two and found this thread. Never heard of Serotonin Storm/Syndrome before in my life. And not a single mention from the doctors.

Was on 30 mg of Adderall, same dose Ive been on for years, and take holidays from it to avoid addiction and or building up a resistance to it. Docs put me on 40 mg of Prozac, said keep taking Adderall. I didnt. I took a holiday from the adderall so I could pick up on any possible side effects from the new Prozac. Once I did begin taking my Adderall again, it almost killed me..... So no... No abuse needed.

Prozac is not supposed to be taken with aspirin, it is written on the label

I take 20 my prozac. ,15mg.adderall, still sad alot, always sleepy! But when I have energy, can't stop

I take 60mg daily of adderall and 40mg of fluoxetine, and they often do have adverse effects even if mild. ive had troubles with indigestion and diarrhea, and occasional auditory hallucinations, though those might be unrelated.